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disease-conditions – Allied Stem Cells

DISEASE AND CONDITIONS

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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

A

Achalasia is a rare disorder that makes it difficult for food and liquid to pass into your stomach. Achalasia occurs when nerves in the tube connecting your mouth and stomach (esophagus) become damaged. As a result, the esophagus loses the ability to squeeze food down, and the muscular valve between the esophagus and stomach (lower esophageal sphincter) doesn’t fully relax — making it difficult for food to pass into your stomach. There’s no cure for achalasia. But symptoms can usually be managed with minimally invasive therapy or surgery (source).

Achilles tendinitis is an overuse injury of the Achilles (uh-KILL-eez) tendon, the band of tissue that connects calf muscles at the back of the lower leg to your heel bone.
Achilles tendinitis most commonly occurs in runners who have suddenly increased the intensity or duration of their runs. It’s also common in middle-aged people who play sports, such as tennis or basketball, only on the weekends.

Most cases of Achilles tendinitis can be treated with relatively simple, at-home care under your doctor’s supervision. Self-care strategies are usually necessary to prevent recurring episodes. More-serious cases of Achilles tendinitis can lead to tendon tears (ruptures) that may require surgical repair.

Addison’s disease is an uncommon autoimmune disease, characterized by chronic and insufficient functioning of the outer layer of the adrenal gland. The adrenal glands are located atop each kidney and produce vital glucocorticoid hormones. Because of this chronic under-functioning of the adrenal glands, persons with Addison’s disease have a deficiency in the production of glucocorticoid hormones. Glucocorticoid hormones are involved in how the body utilizes and stores carbohydrates, protein, fat and blood sugar. The adrenal gland also plays a role in the immune response. A deficiency in glucocorticoid hormones causes an increase in the release of sodium and a decreased release of potassium in the urine, sweat, saliva, stomach and intestines. These changes can cause low blood pressure and increased water excretion that can in some cases lead to severe dehydration. Although there are many underlying factors in the development of adrenal insufficiencies, including destruction of the adrenal cortex due to diseases such as tuberculosis, the growth of tumors, non-autoimmune diseases amyloidosis and adrenoleukodystrophy, and atrophy of the gland due to prolonged use of cortical steroids used in the treatment of other conditions and illnesses, most cases of Addison’s disease are thought to be autoimmune in nature.

Agammaglobulinemia is an immune disorder related to antibody deficiency (hypogammaglobulinemia) and is manifested in a variety of immune deficiency disorders in which the immune system is compromised. This group of immune deficiencies may be the consequence of an inherited condition, an impaired immune system from known or unknown cause, a relation to autoimmune diseases, or a malignancy. Immunoglobulin deficiencies may be referred to by many different names, as there are several variables within the separate but related immune disorders; and there are also many subgroups. Antibody deficiency, immunoglobulin deficiency, and gamma globulin deficiency are all synonyms for hypogammaglobulinemia.

A damaging immune response by the body to a substance, especially pollen, fur, a particular food, or dust, to which it has become hypersensitive. An abnormal reaction of the body to a previously encountered allergen introduced by inhalation, ingestion, injection, or skin contact, often manifested by itchy eyes, runny nose, wheezing, skin rash, or diarrhea.

Alopecia areata is an autoimmune disorder which is characterized by hair loss. Alopecia areata is found equally in both men and women. The disease can occur at any age, including childhood. The hair loss may result in round bald patches on the scalp (alopecia areata) or involve the loss of all facial and scalp hair (alopecia totalis). The loss of all body hair is called alopecia universalis. Alopecia postpartum is characterized by loss of significant hair following pregnancy and is usually temporary. When a patient is diagnosed with alopecia, the first question is usually about whether or not the hair will regrow. The answer is usually vague as each case is different. Regrowth of hair may occur in some patients; and in other, the hair loss is permanent.

Alzheimer’s is the most common cause of dementia, a general term for memory loss and other cognitive abilities serious enough to interfere with daily life. Alzheimer’s disease accounts for 60 percent to 80 percent of dementia cases.. Alzheimer’s is a type of dementia that causes problems with memory, thinking and behavior. Symptoms usually develop slowly and get worse over time, becoming severe enough to interfere with daily tasks.

Amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. The cause of primary amyloidosis is unknown. The condition is related to abnormal and excess production of antibodies by a type of immune cell called plasma cells. Clumps of abnormal proteins build up in certain organs. This reduces their ability to work correctly. Symptoms depend on the organs affected. This disease can affect the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. Symptoms include: abnormal heart rhythm, fatigue, numbness of hands or feet, shortness of breath, hoarseness or changing voice, and joint pain.

Amyotrophic lateral sclerosis or ALS, is a progressive nervous system (neurological) disease that destroys nerve cells and causes disability.
ALS is often called Lou Gehrig’s disease, after the famous baseball player who was diagnosed with it. ALS is a type of motor neuron disease in which nerve cells gradually break down and die.

Doctors usually don’t know why ALS occurs. Some cases are inherited. ALS often begins with muscle twitching and weakness in a limb, or slurred speech. Eventually, ALS affects control of the muscles needed to move, speak, eat and breathe.

Angioedema is a related type of swelling that affects deeper layers in your skin, often around your face and lips. In most cases, hives and angioedema are harmless and don’t leave any lasting marks, even without treatment.

The most common treatment for hives and angioedema is antihistamine medication. Serious angioedema can be life-threatening if swelling causes your throat or tongue to block your airway.

Ankle pain: Pain in the ankle, a “hinged” joint. Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammatory forms of arthritis.

Ankylosing spondylitis is an autoimmune disease and is a type of arthritis of the spine. It causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. The disease is more common and more severe in men. It often runs in families. Early symptoms include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. Symptoms can worsen or improve or stop altogether. The disease has no cure, but medicines can relieve the pain, swelling and other symptoms. Exercise can also help.

An ACL injury is the tearing of the anterior cruciate (KROO-she-ate) ligament (ACL) — one of the major ligaments in your knee. ACL injuries most commonly occur during sports that involve sudden stops, jumping or changes in direction — such as basketball, soccer, football, tennis, downhill skiing, volleyball and gymnastics.

Many people hear or feel a “pop” in the knee when an ACL injury occurs. Your knee may swell, feel unstable and become too painful to bear weight.

What is known is that aging is related to the decline in the body’s ability to regenerate new tissue, causing joints, blood vessels, and other parts of our anatomy to function differently than they do when we are younger.
New evidence indicates that a progressive decline in stem cell frequency and function may significantly contribute to the conditions related to aging…Scientists at the Harvard Stem Cell Institute (HSCI) are studying the aging process in multiple organ systems (muscular, circulatory, nervous, etc.) in order to better understand how we age and develop potential therapeutic interventions (thru Stem Cells).

Some people are hypersensitive to specific antibiotics causing numerious side efftcs or an antibiotic does not destroy the bacteria. Antibiotic resistance: The ability of bacteria and other microorganisms to resist the effects of an antibiotic to which they were once sensitive. Antibiotic resistance is a major concern of overuse of antibiotics. Also known as drug resistance. Antibiotic sensitivity or antibiotic susceptibility is the susceptibility of bacteria to antibiotics.

Anti-GBM/Anti-TBM nephritis: Anti–glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder caused by autoantibodies that attack the walls of small blood vessels (capillaries) in the kidney. Anti-GBM disease that only affects the kidneys is called anti-GBM glomerulonephritis. This is a form of inflammation (-itis), which is injury to tissue caused by white blood cells (leukocytes). Glomerulonephritis due to Anti-GBM antibody disease is rare. It occurs in less than 1 case per million persons. It affects mostly young, white men aged 15-35. After age 50, women are more likely to be affected. The sexes overall are affected approximately at a male-female ratio of 3:2. It is seen very rarely in children. Some evidence suggests that genetics may play an important role in this disease. 60-70% of patients have both lung and kidney involvement. This is called Goodpasture’s Syndrome. 20-40% have only kidney involvement, which is called “renal limited” anti-GBM disease. Symptoms may include: chills and fever, nausea and vomiting, weight loss, chest pain, bleeding may cause anemia, respiratory failure, and kidney failure. Treatment of anti-GBM disease is focused on removing the anti-GBM antibody from the blood

Antiphospholipid syndrome (APS) is an autoimmune syndrome caused by antiphospholipid antibodies. These antibodies are often referred to by different terms, including anticardiolipin antibody, lupus anticoagulant, and antiphospholipid antibody. APS can be primary or secondary, and also can be referred to by the name Hughes syndrome or “sticky blood”.

Arachnoiditis is a type of chronic pain caused by inflammation in the spinal canal.
Arachnoiditis is a chronic pain disorder caused by the inflammation of the arachnoid membrane and subarachnoid space that surround the nerves of the spinal cord. The inflammation can cause the meninges to adhere to the spinal cord and nerve roots. Because the nerve roots are affected, symptoms such as numbness, tingling, and burning pain is often felt in the lower back or legs.

Severe cases of arachnoiditis can result in the loss of motor function, loss of bladder and bowel control and even paralysis. Arachnoiditis can arise from infection, direct spinal injury, and chronic compression of the spinal nerves or invasive spinal surgeries.

Pulmonary hypertension is a type of high blood pressure that affects the arteries in your lungs and the right side of your heart.
In one form of pulmonary hypertension, tiny arteries in your lungs, called pulmonary arterioles, and capillaries become narrowed, blocked or destroyed. This makes it harder for blood to flow through your lungs, and raises pressure within your lungs’ arteries. As the pressure builds, your heart’s lower right chamber (right ventricle) must work harder to pump blood through your lungs, eventually causing your heart muscle to weaken and fail.

Some forms of pulmonary hypertension are serious conditions that become progressively worse and are sometimes fatal. Although some forms of pulmonary hypertension aren’t curable, treatment can help lessen symptoms and improve your quality of life.

Arthropathy is a disease of a joint. Although the terms “arthropathy” and arthritis have very similar meanings, the former is traditionally used to describe the following conditions:
• Reactive arthropathy (M02-M03) is caused by an infection, but not a direct infection of the synovial space. (See also Reactive arthritis)
• Enteropathic arthropathy (M07) is caused by colitis and related conditions.
• Crystal arthropathy (also known as crystal arthritis) (M10-M11) involves the deposition of crystals in the joint.
• In gout, the crystal is uric acid.
• In pseudogout/chondrocalcinosis/calcium pyrophosphate deposition disease, the crystal is calcium pyrophosphate.
• Diabetic arthropathy (M14.2, E10-E14) is caused by diabetes.
• Neuropathic arthropathy (M14.6) is associated with a loss of sensation.

Joint pain can be discomfort, pain or inflammation arising from any part of a joint — including cartilage, bone, ligaments, tendons or muscles. Most commonly, however, joint pain refers to arthritis or arthralgia, which is inflammation or pain from within the joint itself.
Joint pain can be mild, causing soreness only after certain activities, or it can be severe, making even limited movement, particularly bearing weight, extremely painful.

Arthrosis, Degenerative: A type of arthritis caused by inflammation, breakdown, and eventual loss of the cartilage of the joints. Degenerative arthritis is the most common form of arthritis, usually affecting the hands, feet, spine, and large weight-bearing joints, such as the hips and knees. Also known as osteoarthritis and degenerative joint disease.

Asperger syndrome (AS), also known as Asperger’s, is a developmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behavior and interests.[3] As a milder autism spectrum disorder (ASD), it differs from other ASDs by relatively normal language and intelligence.[6] Although not required for diagnosis, physical clumsiness and unusual use of language are common.[7][8] Signs usually begin before two years old and typically last for a person’s entire life.

Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. These episodes may occur a few times a day or a few times per week. Depending on the person, they may become worse at night or with exercise.
Asthma is thought to be caused by a combination of genetic and environmental factors. Environmental factors include exposure to air pollution and allergens. Other potential triggers include medications such as aspirin and beta blockers. Diagnosis is usually based on the pattern of symptoms, response to therapy over time, and spirometry. Asthma is classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. It may also be classified as atopic or non-atopic, where atopy refers to a predisposition toward developing a type 1 hypersensitivity reaction.

Asthma is a chronic lung disease that inflames and narrows the airways. Asthma causes recurring periods of wheezing (a whistling sound when you breathe), chest tightness, shortness of breath, and coughing. The coughing often occurs at night or early in the morning.
Asthma affects people of all ages, but it most often starts during childhood. In the United States, more than 25 million people are known to have asthma. About 7 million of these people are children.

Ataxia describes a lack of muscle control or coordination of voluntary movements, such as walking or picking up objects. A sign of an underlying condition, ataxia can affect various movements, creating difficulties with speech, eye movement and swallowing.
Persistent ataxia usually results from damage to the part of your brain that controls muscle coordination (cerebellum). Many conditions can cause ataxia, including alcohol abuse, certain medications, stroke, tumor, cerebral palsy, brain degeneration and multiple sclerosis. Inherited defective genes also can cause the condition.

Arteriosclerosis occurs when the blood vessels that carry oxygen and nutrients from your heart to the rest of your body (arteries) become thick and stiff — sometimes restricting blood flow to your organs and tissues. Healthy arteries are flexible and elastic, but over time, the walls in your arteries can harden, a condition commonly called hardening of the arteries.

Atherosclerosis is a specific type of arteriosclerosis, but the terms are sometimes used interchangeably. Atherosclerosis refers to the buildup of fats, cholesterol and other substances in and on your artery walls (plaque), which can restrict blood flow.
The plaque can burst, triggering a blood clot. Although atherosclerosis is often considered a heart problem, it can affect arteries anywhere in your body. Atherosclerosis may be preventable and is treatable.

Autism spectrum disorder is a condition related to brain development that impacts how a person perceives and socializes with others, causing problems in social interaction and communication. The disorder also includes limited and repetitive patterns of behavior. The term “spectrum” in autism spectrum disorder refers to the wide range of symptoms and severity.

Autism spectrum disorder includes conditions that were previously considered separate — autism, Asperger’s syndrome, childhood disintegrative disorder and an unspecified form of pervasive developmental disorder. Some people still use the term “Asperger’s syndrome,” which is generally thought to be at the mild end of autism spectrum disorder.
Autism spectrum disorder begins in early childhood and eventually causes problems functioning in society — socially, in school and at work, for example. Often children show symptoms of autism within the first year. A small number of children appear to develop normally in the first year, and then go through a period of regression between 18 and 24 months of age when they develop autism symptoms.

An autoimmune disease is a condition in which your immune system mistakenly attacks your body. … Normally, the immune system can tell the difference between foreign cells and your own cells. In an autoimmune disease, the immune system mistakes part of your body — like your joints or skin — as foreign.

Autoinflammatory diseases refer to problems with the immune system, which usually fights off viruses, bacteria, and infection. It results when your immune cells attack your body by mistake. … In most cases, your doctor will prescribe medications to reduce pain and swelling or that act on the immune system.

Axonal & neuronal neuropathy (AMAN) is a variant of Guillain-Barré syndrome, an autoimmune disease. It is characterized by acute paralysis and loss of reflexes without sensory loss. The syndrome typically presents as a progressive symmetric paralysis (loss of muscle function) with areflexia (absence of neurologic reflexes such as the knee jerk reaction), often causing respiratory failure. Antibodies attack the coating of the motor neurons without causing inflammation. It does not affect sensory neurons, so sensation remains intact despite loss of movement.

B

Babesiosis is a rare, sometimes severe, disease caused by the bite of a tick infected with Babesia microti, a microscopic (tiny, not seen without a microscope) parasite that infects red blood cells. In New York State, the Babesia species that infects people is Babesia microti, which is spread by the bite of an infected blacklegged (or deer) tick. Babesiosis can affect people of any age.

Baló’s concentric sclerosis (BCS) is a rare disorder usually considered a variant of multiple sclerosis (MS). However, its correlation with MS remains unclear and controversial. Baló’s disease is a demyelinating (damage to the nerve sheath) disorder of the central nervous system in which the myelin (the fatty substance covering nerve fibers) is damaged.  It is characterized by a severe, rapidly evolving clinical course, and by unusual nervous system changes.  Often large tumor-like plaques (lesions) that are found to destroy the sheath of the nerve are present. Studies indicate that autoimmune factors may play a role in its development. Autoimmune disorders are caused when the body’s natural defenses against “foreign” or invading organisms begin to attack healthy tissue for unknown reasons resulting in inflammation (swelling). Baló’s disease appears to be most common in Asians and in people from the Philippines; it affects males and females with similar frequency. Baló’s disease usually appears in adulthood but childhood cases have been reported.

Becker muscular dystrophy: Signs and symptoms are similar to those of Duchenne muscular dystrophy, but tend to be milder and progress more slowly. Symptoms generally begin in the teens but may not occur until the mid-20s or even later.
See Duchenne muscular dystrophy.

Behcet’s disease is a chronic, multisystem autoimmune disease involving inflammation of blood vessels, called vasculitis, throughout the body. It is a rare disease, most commonly found in the Eastern Mediterranean countries and in eastern Asia. It affects more young men than women in those countries, but in the US it affects more women, most often in their 20s and 30s. The central nervous system, heart, and intestinal tract may be involved. Because this disease is so rare and it’s symptoms overlap those of other diseases, it may be very difficult to diagnose. Spontaneous remission may occur, which can add to the difficulty in diagnosis.

Cicatricial pemphigoid (also known as benign mucosal pemphigoid, mucous membrane pemphigoid, or benign mucous membrane pemphigoid) is a rare chronic autoimmune blistering disease characterized by erosive skin lesions of the mucous membranes and skin that results in scarring of at least some sites of involvement. The autoimmune reaction most commonly affects the mouth, causing lesions in the gums, but it can also affect areas of mucous membrane elsewhere in the body, such as the sinuses, genitals and anus. When the cornea of the eye is affected, repeated scarring may result in blindness. The management depends upon the severity of the condition. Simple measures that can be taken include avoidance of hard, sharp or rough foods, and taking care when eating. Good oral hygiene is also usually advised, and professional oral hygiene measures such as periodontal scaling.

Perhaps the simplest and most frequently done cosmetic stem cell procedure is injecting stem cells into the skin and supporting tissues of the face. The face is numbed using a topical cream. Stem cells are injected directly into the face using small needles. This has come to be referred to as a “Stem Cell Face Lift”. While this has been shown to tighten the skin, improve small lines, and lighten age spots, it DOES NOT do what a surgical face lift can do. Its’ advantages are a facial rejuvenation without significant downtime. Multiple injections are required, but the procedure is very safe and requires only local and topical anesthesia. Stem Cell therapy is still considered investigational and procedures are done “off-label”

Bone spurs are bony projections that develop along bone edges. Bone spurs (osteophytes) often form where bones meet each other — in your joints. They can also form on the bones of your spine.
The main cause of bone spurs is the joint damage associated with osteoarthritis. Most bone spurs cause no symptoms and can go undetected for years. They might not require treatment. If treatment is needed, it depends on where spurs are located and how they affect your health.

Most bone spurs cause no signs or symptoms. You might not realize you have bone spurs until an X-ray for another condition reveals the growths. In some cases, though, bone spurs can cause pain and loss of motion in your joints.
Specific symptoms depend on where the bone spurs are. Examples include:
* Knee. Bone spurs in your knee can make it painful to extend and bend your leg.
* Spine. On your vertebrae, bone spurs can narrow the space that contains your spinal cord. These bone spurs can pinch the spinal cord or its nerve roots and can cause weakness or numbness in your arms or legs.
* Hip. Bone spurs can make it painful to move your hip, although you might feel the pain in your knee. Depending on their placement, bone spurs can reduce the range of motion in your hip joint.

Buerger’s disease (thromboangiitis obliterans) is a rare disease of the arteries and veins in the arms and legs. In Buerger’s disease, your blood vessels become inflamed, swell and can become blocked with blood clots (thrombi).
This eventually damages or destroys skin tissues and may lead to infection and gangrene. Buerger’s disease usually first shows in your hands and feet and may eventually affect larger areas of your arms and legs.

Virtually everyone diagnosed with Buerger’s disease smokes cigarettes or uses other forms of tobacco, such as chewing tobacco. Quitting all forms of tobacco is the only way to stop Buerger’s disease. For those who don’t quit, amputation of all or part of a limb is sometimes necessary.

Bullous pemphigoid is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Bullous pemphigoid does not spread from person to person. It does not appear to be inherited. But some people’s genes put them more at risk for bullous pemphigoid. Bullous pemphigoid is most common in older adults and may be fatal for older, sick patients. Bullous pemphigoid usually occurs in elderly persons and is rare in young people.

C

A calcaneal spur (or heel spur) is a bony outgrowth from the calcaneal tuberosity (heel bone). Calcaneal spurs are typically detected by a radiographic examination (commonly referred to as an “x-ray”). When a foot is exposed to constant stress, calcium deposits build up on the bottom of the heel bone.

Cardiomyopathy (kahr-dee-o-my-OP-uh-thee) is a disease of the heart muscle that makes it harder for your heart to pump blood to the rest of your body. Cardiomyopathy can lead to heart failure.
The main types of cardiomyopathy include dilated, hypertrophic and restrictive cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle (myocardium) becomes abnormally thick (hypertrophied). The thickened heart muscle can make it harder for the heart to pump blood.

Carpal tunnel syndrome is a condition that causes numbness, tingling and other symptoms in the hand and arm. Carpal tunnel syndrome is caused by a compressed nerve in the carpal tunnel, a narrow passageway on the palm side of your wrist.
The anatomy of your wrist, health problems and possibly repetitive hand motions can contribute to carpal tunnel syndrome.

Proper treatment usually relieves the tingling and numbness and restores wrist and hand function.

Oroya fever or Carrion’s disease is an infectious disease produced by Bartonella bacilliformis infection.

Castleman disease (CD) is a rare disease of lymph nodes and related tissues. It is also called giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH). Castleman disease can occur in a localized (unicentric) or widespread (multicentric) form. It was first described by Dr. Benjamin Castleman in the 1950s. CD is not cancer. Instead, it is called a lymphoproliferative disorder. This means there is an abnormal overgrowth of cells of the lymph system that is similar in many ways to lymphomas (cancers of lymph nodes). Treatment and outlook vary, depending on the type of Castleman disease you have. The localized type can usually be successfully treated with surgery. Sometimes associated with HIV infection, multicentric Castleman disease can be life-threatening. Multicentric Castleman disease is also associated with other cell-proliferation disorders, including Kaposi’s sarcoma and POEMS syndrome.

Celiac disease is an autoimmune disease in which people can’t eat gluten because it will damage their small intestine. If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. Gluten is a protein found in wheat, rye, and barley. It is found mainly in foods but may also be in other products like medicines, vitamins and supplements, lip balm, and even the glue on stamps and envelopes. Celiac disease affects each person differently. Symptoms may occur in the digestive system, or in other parts of the body. One person might have diarrhea and abdominal pain, while another person may be irritable or depressed. Irritability is one of the most common symptoms in children. Some people have no symptoms. (see also Dermatitis Herpetiformis).

Central retinal vein occlusion (CRVO) is a blockage of this vein that causes the vein to leak blood and excess fluid into the retina. This fluid often collects in the area of the retina responsible for central vision called the macula. When the macula is affected, central vision may become blurry.

Central retinal vein occlusion (CRVO) is a blockage of this vein that causes the vein to leak blood and excess fluid into the retina. This fluid often collects in the area of the retina responsible for central vision called the macula. When the macula is affected, central vision may become blurry.

Cerebral palsy is a disorder of movement, muscle tone or posture that is caused by damage that occurs to the immature, developing brain, most often before birth.
Signs and symptoms appear during infancy or preschool years. In general, cerebral palsy causes impaired movement associated with abnormal reflexes, floppiness or rigidity of the limbs and trunk, abnormal posture, involuntary movements, unsteady walking, or some combination of these.

People with cerebral palsy may have problems swallowing and commonly have eye muscle imbalance, in which the eyes don’t focus on the same object. People with cerebral palsy also may suffer reduced range of motion at various joints of their bodies due to muscle stiffness.
Cerebral palsy’s effect on functional abilities varies greatly. Some affected people can walk while others can’t. Some people show normal or near-normal intellectual capacity, but others may have intellectual disabilities. Epilepsy, blindness or deafness also may be present.

Chagas disease is caused by a parasite called Trypanosoma cruzi, sometimes called a kissing bug and related to the African trypanosome that causes sleeping sickness. It is one of the major health problems in South America. Due to immigration, the disease also affects people in the United States. The infected blood-sucking bugs spread it. When the bug bites you, usually on your face, it leaves behind infected waste. You can get the infection if you rub it in your eyes or nose, the bite wound or a cut. The disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. If you notice symptoms, they might include: fever, flu-like symptoms, a rash, or a swollen eyelid. These early symptoms usually go away. However, if you don’t treat the infection, it stays in your body. Later, it can cause serious intestinal and heart problems. A physical exam and blood tests can diagnose it. You may also need tests to see whether the disease has affected your intestines and heart. Medicines can kill the parasite, especially early on. You can also treat related problems.

Chronic bronchitis is one of the two most common conditions that contribute to COPD. Chronic bronchitis is inflammation of the lining of the bronchial tubes, which carry air to and from the air sacs (alveoli) of the lungs. It’s characterized by daily cough and mucus (sputum) production.

Chronic fatigue syndrome (CFS) is a complicated disorder characterized by extreme fatigue that can’t be explained by any underlying medical condition. The fatigue may worsen with physical or mental activity, but doesn’t improve with rest.
This condition is also known as systemic exertion intolerance disease (SEID) or myalgic encephalomyelitis (ME). Sometimes it’s abbreviated as ME/CFS.

The cause of chronic fatigue syndrome is unknown, although there are many theories — ranging from viral infections to psychological stress. Some experts believe chronic fatigue syndrome might be triggered by a combination of factors.

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disorder in which there is swelling of nerve roots and destruction of the covering (myelin sheath) over the nerves. This causes weakness, paralysis, and/or impairment in motor function, especially of the arms and legs. Sensory loss may also be present, causing numbness, tingling, and burning sensations. The motor and sensory impairments are usually found on both sides of the body. The severity of CIDP can vary from mild to severe. CIDP can affect any age group, and the onset may begin anytime throughout life.

Intractable pain, also known as Intractable Pain Disease or IP, is a severe, constant pain that is not curable by any known means and which causes a bed or house-bound state and early death if not adequately treated, usually with opioids and/or interventional procedures.

Chronic pain syndrome (CPS) is a common problem that presents a major challenge to health-care providers because of its complex natural history, unclear etiology, and poor response to therapy. CPS is a poorly defined condition. In chronic pain, the duration parameter is used arbitrarily.

Prostatitis is swelling and inflammation of the prostate gland, a walnut-sized gland situated directly below the bladder in men. The prostate gland produces fluid (semen) that nourishes and transports sperm. Prostatitis often causes painful or difficult urination. Other symptoms include pain in the groin, pelvic area or genitals and sometimes flu-like symptoms. Prostatitis affects men of all ages but tends to be more common in men 50 or younger. The condition has a number of causes. Sometimes the cause isn’t identified. If prostatitis is caused by a bacterial infection, it can usually be treated with antibiotics. Depending on the cause, prostatitis can come on gradually or suddenly. It might improve quickly, either on its own or with treatment. Some types of prostatitis last for months or keep recurring (chronic prostatitis).

Chronic recurrent multifocal osteomyelitis (CRMO) Although its definition is still evolving, many doctors and articles describe CRMO as an autoimmune related disease. The origin of this disease however, is unclear. It is “multifocal” because it can erupt in different sites, primarily in bones. It is a rare condition (1:1,000,000). It comprises periodic bone pain, fever, and the appearance of multiple bone lesions that can occur in any skeletal site. Genetics appears to play a role, but the diagnosis can be difficult. Although adults can be affected, CRMO most often affects children, more commonly girls than boys. The peak age of incidence is around 10 years, with the range being 4 to 55 years. Children show symptoms ranging from pain, deep aching pain, limping, to fever. The metaphyseal area of long bones, the clavicle, and the shoulder girdle are common locations where CRMO is found. Other sites such as the spine, ankle, and foot have been reported. Dermatological (skin) manifestations may occur and include psoriasis, acne, and pustules on the palms of the hands and soles of the feet.

Complex regional pain syndrome (CRPS) is a form of chronic pain that usually affects an arm or a leg. CRPS typically develops after an injury, a surgery, a stroke or a heart attack. The pain is out of proportion to the severity of the initial injury. Complex regional pain syndrome is uncommon, and its cause isn’t clearly understood. Treatment is most effective when started early. In such cases, improvement and even remission are possible.

Churg-Strauss syndrome, also known as allergic granulomatosis or eosinophilic granulomatosis with polyangiitis (EGPA) is an autoimmune disorder characterized by accumulated antibodies, inflammation of blood vessels, and abnormal clustering of white blood cells. An allergic reaction or asthma may precede the syndrome’s development by several years. Although Churg-Strauss syndrome patients may have a prior history of pulmonary disease, the syndrome tends to impair kidneys or other organs or to cause nerve damage in affected areas. Diagnosis is difficult because early symptoms mimic common flu. Lung tissue infiltrations (short-term or persistent), fever, and weight loss are often initial signs. Prompt diagnosis and treatment (with corticosteroids) increase a patient’s chances of resuming a normal life. Onset typically occurs from 15-70 years of age, and the disease affects both males and females.

Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. The liver carries out several necessary functions, including detoxifying harmful substances in your body, cleaning your blood and making vital nutrients. Cirrhosis occurs in response to damage to your liver. Each time your liver is injured, it tries to repair itself. In the process, scar tissue forms. As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function. Decompensated cirrhosis is the term used to describe the development of specific complications resulting from the changes brought on by cirrhosis. Decompensated cirrhosis is life-threatening. The liver damage done by cirrhosis generally can’t be undone. But if liver cirrhosis is diagnosed early and the cause is treated, further damage can be limited and, rarely, reversed.

Cogan’s syndrome is defined as nonsyphilitic interstitial keratitis (an inflammation of the eye) and bilateral audiovestibular deficits (hearing problems and dizziness). It is more common in Caucasians than in other races. Onset of the disease is generally a brief episode of inflammatory eye disease, most commonly interstitial keratitis. This eye condition causes pain, lacrimation (tearing of the eye) and photophobia (eye pain with exposure to light). Shortly following these ocular (eye) symptoms, patients develop bilateral audiovestibular (ear) symptoms, including hearing loss, vertigo (dizziness) and tinnitus (ringing in the ears). Approximately half of patients ultimately develop complete hearing loss, but only a minority experience permanent visual loss. Other symptoms that may occur include headache, fever, arthralgia (joint pain), and systemic vasculitis (inflammation of the blood vessels). The symptoms typically deteriorate progressively within days. It is currently thought that Cogan’s syndrome is an autoimmune disease. The inflammation in the eye and ear are due to the patient’s own immune system producing antibodies that attack the inner ear and eye tissue.

Cold agglutinin disease is a form of autoimmune hemolytic anemia caused by cold-reacting autoantibodies (a type of protein produced by the immune system). Primary cold agglutinin disease is usually associated with monoclonal (produced from a single ancestral cell by repeated cellular replication) cold-reacting autoantibodies. Primary cold agglutinin disease is chronic and occurs after the fifth decade of life, with a peak incidence in the seventh and eighth decades. Secondary cold agglutinin disease is predominantly caused by infection and lymphoproliferative disorders in which lymphocytes (white blood cells) are produced in excessive quantities. It is essential with chronic cold agglutinin disease to keep all body parts warm at all times and avoid cooling of body parts. Appropriate clothing is necessary for cold environments, and avoidance of cold foods and working in cold storage areas is also important.

Ulcerative colitis is an inflammatory bowel disease (IBD) that causes long-lasting inflammation and ulcers (sores) in your digestive tract. Ulcerative colitis affects the innermost lining of your large intestine (colon) and rectum. Symptoms usually develop over time, rather than suddenly. Ulcerative colitis can be debilitating and can sometimes lead to life-threatening complications. While it has no known cure, treatment can greatly reduce signs and symptoms of the disease and even bring about long-term remission.

Congenital heart block is a rare complication of pregnancy associated with Sjögren Syndrome (an autoimmune syndrome) that may result in the death of the fetus or infant, or the need for pacing in the newborn or at a later stage. Doctors might detect congenital heart block before or after a baby is born. Certain diseases that may occur during pregnancy can cause heart block in a baby. Heart block is a problem that occurs with the heart’s electrical system. This system controls the rate and rhythm of heartbeats. (“Rate” refers to the number of times your heart beats per minute. “Rhythm” refers to the pattern of regular or irregular pulses produced as the heart beats.) With each heartbeat, an electrical signal spreads across the heart from the upper to the lower chambers. As it travels, the signal causes the heart to contract and pump blood. Heart block occurs if the electrical signal is slowed or disrupted as it moves through the heart.

Congenital. This type affects boys and girls and is apparent at birth or before age 2. Some forms progress slowly and cause only mild disability, while others progress rapidly and cause severe impairment.

Heart failure, sometimes known as congestive heart failure, occurs when your heart muscle doesn’t pump blood as well as it should. Certain conditions, such as narrowed arteries in your heart (coronary artery disease) or high blood pressure, gradually leave your heart too weak or stiff to fill and pump efficiently. Not all conditions that lead to heart failure can be reversed, but treatments can improve the signs and symptoms of heart failure and help you live longer. Lifestyle changes — such as exercising, reducing sodium in your diet, managing stress and losing weight — can improve your quality of life.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing. It’s caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke. People with COPD are at increased risk of developing heart disease, lung cancer and a variety of other conditions. Emphysema and chronic bronchitis are the two most common conditions that contribute to COPD. Chronic bronchitis is inflammation of the lining of the bronchial tubes, which carry air to and from the air sacs (alveoli) of the lungs. It’s characterized by daily cough and mucus (sputum) production. Emphysema is a condition in which the alveoli at the end of the smallest air passages (bronchioles) of the lungs are destroyed as a result of damaging exposure to cigarette smoke and other irritating gases and particulate matter.

Blurred vision refers to a lack of sharpness of vision resulting in the inability to see fine detail. Blurred vision may result from abnormalities present at birth such as nearsightedness or farsightedness that require corrective lenses (glasses) or it may signal the presence of eye disease.

A corneal ulcer is a corneal epithelial defect with underlying inflammation (which soon results in necrosis of corneal tissue) due to invasion by bacteria, fungi, viruses, or Acanthamoeba. It can be initiated by mechanical trauma or nutritional deficiencies.

Perhaps the simplest and most frequently done cosmetic stem cell procedure is injecting stem cells into the skin and supporting tissues of the face. The face is numbed using a topical cream. Stem cells are injected directly into the face using small needles. This has come to be referred to as a “Stem Cell Face Lift”. While this has been shown to tighten the skin, improve small lines, and lighten age spots, it DOES NOT do what a surgical face lift can do. Its’ advantages are a facial rejuvenation without significant downtime. Multiple injections are required, but the procedure is very safe and requires only local and topical anesthesia. Stem Cell therapy is still considered investigational and procedures are done “off-label”.

Coxsackie myocarditis is inflammation and weakness of the heart muscle caused by a viral infection (Coxsackie virus) that reaches the heart. Myocarditis can damage the heart muscle causing it to become thick and swollen. The heart muscle may be directly damaged by the virus or the bacteria that infect it. The body’s immune response can also damage the heart muscle (called the myocardium) in the process of fighting the infection. This can lead to symptoms of heart failure. Symptoms may include: anxiousness, failure to thrive or poor weight gain, feeding difficulties, fever and other symptoms of infection, listlessness, low urine output (a sign of decreasing kidney function), pale, cool hands and feet (a sign of poor circulation), rapid breathing, and rapid heart rate. Myocarditis may also occur during or after other viral or bacterial infections such as the influenza (flu) virus, adenovirus, polio, rubella, Lyme disease, and others. Myocarditis is rare in young children. It is slightly more common in older children and adults. It is often worse in newborns and young infants than in children over age 2. There is no cure for myocarditis. The heart muscle inflammation will often go away on its own.

CREST syndrome is an acronym for calcinosis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. It is a variant of the two groups of scleroderma, localized and systemic. CREST is a relatively stable and slow-moving form of scleroderma and has a much more favorable prognosis than other forms. There is no evidence that the basic process differs from the usual scleroderma, but the tempo of CREST seems to be different in that organ involvement comes slower and later in the course of the disease.

Crohn’s disease is an inflammatory autoimmune bowel disease characterized by severe and persistent inflammation of the lining or wall of the gastrointestinal tract. Crohn’s is sometimes referred to as chronic ileitis, regional enteritis, or granulomatous colitis. The part of the gastrointestinal tract most commonly affected is the segment between the ileum and the rectum. Although Crohn’s disease can be difficult to manage and live with, it is usually not life threatening.

The ulnar nerve is one of the three main nerves in your arm. … Ulnar nerve compression at the elbow is called “cubital tunnel syndrome.” Numbness and tingling in the hand and fingers are common symptoms of cubital tunnel syndrome.

Cystic fibrosis is an inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body. Cystic fibrosis affects the cells that produce mucus, sweat and digestive juices. These secreted fluids are normally thin and slippery. But in people with cystic fibrosis, a defective gene causes the secretions to become sticky and thick. Instead of acting as a lubricant, the secretions plug up tubes, ducts and passageways, especially in the lungs and pancreas.

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Medical Definition of Degenerative arthritis. Degenerative arthritis is the most common form of arthritis, usually affecting the hands, feet, spine, and large weight-bearing joints, such as the hips and knees. Also known as osteoarthritis and degenerative joint disease.

Medical Definition of Degenerative arthritis. Degenerative arthritis is the most common form of arthritis, usually affecting the hands, feet, spine, and large weight-bearing joints, such as the hips and knees. Also known as osteoarthritis and degenerative joint disease.

Dementia isn’t a specific disease. Instead, dementia describes a group of symptoms affecting memory, thinking and social abilities severely enough to interfere with daily functioning. Though dementia generally involves memory loss, memory loss has different causes. So memory loss alone doesn’t mean you have dementia. Alzheimer’s disease is the most common cause of a progressive dementia in older adults, but there are a number of causes of dementia. Depending on the cause, some dementia symptoms can be reversed.

Dermatitis herpetiformis is an extremely itchy rash consisting of bumps and blisters. The rash is chronic, which means it continues over a long period. Dermatitis herpetiformis usually begins in people age 20 and older. Children can sometimes be affected. It is seen in both men and women. The cause is unknown. It is thought to be an autoimmune disorder. Dermatitis herpetiformis is also linked to gluten sensitivity (celiac sprue disease) in the small bowel. Symptoms of dermatitis herpetiformis tend to come and go. Symptoms include: extremely itchy bumps or blisters, most often on the elbows, knees, back, and buttocks. The rash is usually the same size and shape on both sides. The rash can look like eczema. Some patients may have scratch marks instead of blisters. A strict gluten-free diet will be recommended to help control the disease. Sticking to this diet may eliminate the need for medications and prevent later complications. The disease may be well-controlled with treatment. Without treatment, there may be a significant risk of intestinal cancer.

The more common dermatologic conditions that require treatment include acne, dermatitis, and eczema. Skin rashes are one of the most common dermatologic conditions. Dermatologic means of or relating to the skin.

Dermatomyositis is an autoimmune muscle disease that involves inflammation and a skin rash. It is a type of inflammatory myopathy. The cause of dermatomyositis is unknown. Experts think it may be due to a viral infection of the muscles or a problem with the body’s immune system. It may also occur in patients who have cancer in the abdomen, lung, or other parts of the body. Anyone can develop dermatomyositis. It most commonly occurs in children age 5 – 15 and adults age 40 – 60. Women develop this condition more often than men. Symptoms may include: problems swallowing, muscle weakness, stiffness, or soreness, purple color to the upper eyelids, purple-red skin rash, and shortness of breath. The muscle weakness may come on suddenly or develop slowly over weeks or months. You may have trouble raising your arms over your head, getting up from a sitting position, and climbing stairs. The rash may appear on your face, knuckles, neck, shoulders, upper chest, and back. Symptoms may go away completely in some people, such as children. The condition may be fatal in adults due to severe muscle weakness, malnutrition, pneumonia, or lung failure. The major causes of death with this condition are cancer and lung disease.

Devic’s disease (see neuromyelitis optica) is an autoimmune condition that affects the spinal cord and optic nerves (the nerves that carry information regarding sight from the eye). In Devic disease, the body’s immune system attacks and destroys myelin, a fatty substance that surrounds nerves and helps nerve signals move from cell to cell. Signs and symptoms worsen with time and include optic neuritis; transverse myelitis; pain in spine and limbs; and bladder and bowel dysfunction. The exact cause of Devic’s disease is unknown. Most affected people do not have other family members with the condition. Currently there is no cure for Devic’s disease, but there are therapies to treat an attack while it is happening, to reduce symptoms, and to prevent relapses.

Diabetes mellitus refers to a group of diseases that affect how your body uses blood sugar (glucose). Glucose is vital to your health because it’s an important source of energy for the cells that make up your muscles and tissues. It’s also your brain’s main source of fuel. The underlying cause of diabetes varies by type. But, no matter what type of diabetes you have, it can lead to excess sugar in your blood. Too much sugar in your blood can lead to serious health problems. Chronic diabetes conditions include type 1 diabetes and type 2 diabetes. Potentially reversible diabetes conditions include prediabetes — when your blood sugar levels are higher than normal, but not high enough to be classified as diabetes — and gestational diabetes, which occurs during pregnancy but may resolve after the baby is delivered.

Type 1 diabetes – Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young adults but can appear at any age. Symptoms may include, being very thirsty, urinating often, feeling very hungry or tired, losing weight without trying, having sores that heal slowly, having dry, itchy skin, losing the feeling in your feet or having tingling in your feet, and having blurry eyesight. A blood test can show if you have diabetes. If you do, you will need to take insulin for the rest of your life.

Type 2 diabetes, once known as adult-onset or noninsulin-dependent diabetes, is a chronic condition that affects the way your body metabolizes sugar (glucose), your body’s important source of fuel. With type 2 diabetes, your body either resists the effects of insulin — a hormone that regulates the movement of sugar into your cells — or doesn’t produce enough insulin to maintain a normal glucose level.

A diabetic foot is a foot that exhibits any pathology that results directly from diabetes mellitus or any long-term (or “chronic”) complication of diabetes mellitus. … Due to the peripheral nerve dysfunction associated with diabetes (diabetic neuropathy), patients have a reduced ability to feel pain.

Diabetic neuropathy is a type of nerve damage that can occur if you have diabetes. High blood sugar (glucose) can injure nerves throughout your body. Diabetic neuropathy most often damages nerves in your legs and feet. Depending on the affected nerves, symptoms of diabetic neuropathy can range from pain and numbness in your legs and feet to problems with your digestive system, urinary tract, blood vessels and heart. Some people have mild symptoms. But for others, diabetic neuropathy can be quite painful and disabling. Diabetic neuropathy is a common and serious complication of diabetes. But you can often prevent diabetic neuropathy or slow its progress with tight blood sugar control and a healthy lifestyle.

Diabetic retinopathy (die-uh-BET-ik ret-ih-NOP-uh-thee) is a diabetes complication that affects eyes. It’s caused by damage to the blood vessels of the light-sensitive tissue at the back of the eye (retina). At first, diabetic retinopathy may cause no symptoms or only mild vision problems. Eventually, it can cause blindness. The condition can develop in anyone who has type 1 or type 2 diabetes. The longer you have diabetes and the less controlled your blood sugar is, the more likely you are to develop this eye complication.

A diabetic foot ulcer is an open sore or wound that occurs in approximately 15 percent of patients with diabetes and is commonly located on the bottom of the foot. Of those who develop a foot ulcer, 6 percent will be hospitalized due to infection or other ulcer-related complication.

Diffuse axonal injury (DAI) is a brain injury in which extensive lesions in white matter tracts occur over a widespread area. It occurs in about half of all cases of severe head trauma and may be the primary damage that occurs in concussion.

Lupus is a chronic inflammatory autoimmune disease. There are three common types of lupus. Systemic Lupus Erythematosus (SLE) is the most serious. SLE can affect almost any organ or system in the body including blood vessels, muscles, joints, the digestive tract, lungs, kidneys, heart and central nervous system. * Discoid lupus causes a raised, scaly, red rash, usually on the face, scalp and neck and may cause scarring. * Drug-induced lupus is a type of lupus which is caused by prescription medications. Symptoms are similar to those of SLE; and once the medication is stopped, the symptoms usually cease. * Neonatal lupus is a rare disease that can affect some newborn babies of women with SLE or certain other immune system disorders. These babies may have a heart defect, skin rash, low blood count, and/or liver problems. However, most infants of mothers with SLE are born healthy.

Distal muscular dystrophy (DD) is a group of rare diseases that affect your muscles (genetic myopathies). DD causes weakness that starts in the lower arms and legs (the distal muscles). It then may gradually spread to affect other parts of your body. The muscles shrink (atrophy).

Dressler’s syndrome is a type of pericarditis, inflammation of the sac surrounding the heart (pericardium). Inflammation associated with Dressler’s syndrome is believed to be an immune system response following damage to heart tissue or the pericardium, such as a heart attack, surgery or traumatic injury. Dressler’s syndrome symptoms include chest pain, much like that experienced during a heart attack, and fever. With recent improvements in heart attack treatment, Dressler’s syndrome is less common than it used to be. However, once you’ve had this condition, it may happen again. Dressler’s syndrome may also be called postpericardiotomy, post-myocardial infarction syndrome, and post-cardiac injury syndrome. Symptoms are likely to appear weeks to months after a heart attack, surgery or other heart injury.

Dry eyes is a common condition that occurs when your tears aren’t able to provide adequate lubrication for your eyes. Tears can be inadequate for many reasons. For example, dry eyes may occur if you don’t produce enough tears or if you produce poor-quality tears. Dry eyes feel uncomfortable.

Duchenne type muscular dystrophy This is the most common form of muscular dystrophy. Although girls can be carriers and mildly affected, it’s much more common in boys. About one-third of boys with Duchenne muscular dystrophy (DMD) don’t have a family history of the disease, possibly because the gene involved may be subject to sudden abnormal change (spontaneous mutation). Signs and symptoms typically appear in early childhood and may include: Frequent falls Difficulty rising from a lying or sitting up position Trouble running and jumping Waddling gait Walking on the toes Large calf muscles Muscle pain and stiffness Learning disabilities

Dysautonomia refers to a disorder of autonomic nervous system (ANS) function that generally involves failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive or overactive ANS actions also can occur.

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Atopic dermatitis (eczema) is a condition that makes your skin red and itchy. It’s common in children but can occur at any age. Atopic dermatitis is long lasting (chronic) and tends to flare periodically. It may be accompanied by asthma or hay fever.

The ulnar nerve is one of the three main nerves in your arm. … Ulnar nerve compression at the elbow is called “cubital tunnel syndrome.” Numbness and tingling in the hand and fingers are common symptoms of cubital tunnel syndrome.

Your elbow joint is made up of bone, cartilage, ligaments and fluid. Tendinitis of the elbow is a sports injury, often from playing tennis or golf. You may also get tendinitis from overuse of the elbow. Other causes of elbow pain include sprains, strains, fractures, dislocations, bursitis and arthritis.

Tennis elbow, also known as lateral epicondylitis, is a condition in which the outer part of the elbow becomes painful and tender. The pain may also extend into the back of the forearm and grip strength may be weak. It is due to excessive use of the muscles of the back of the forearm.

Emery-Dreifuss muscular dystrophy (EDMD) is one of nine types of muscular dystrophy, a group of genetic, degenerative diseases primarily affecting voluntary muscles. It is named for Alan Emery and Fritz Dreifuss, physicians who first described the disorder among a Virginia family in the 1960s.

Emphysema is one of the most common conditions that contribute to COPD. Emphysema is a condition in which the alveoli at the end of the smallest air passages (bronchioles) of the lungs are destroyed as a result of damaging exposure to cigarette smoke and other irritating gases and particulate matter.

Encephalomyelitis: Inflammation of both the brain and the spinal cord. Encephalomyelitis can be caused by a variety of conditions, including viruses that infect the nervous system. One type of encephalomyelitis, acute disseminatedencephalomyelitis, occurs most commonly after an acute viral infection, such as measles (rubeola). It is due to an autoimmune attack on the nervous system, meaning that the immune system mistakenly attacks body tissue that it believes to be the measles virus. Also known as myeloencephalitis.

Chronic traumatic encephalopathy (CTE) is the term used to describe brain degeneration likely caused by repeated head traumas. CTE is a diagnosis only made at autopsy by studying sections of the brain. CTE is a very rare condition. It has been found in the brains of people who played contact sports, such as football, as well as others. Some symptoms of CTE are thought to include difficulties with thinking (cognition), physical problems, emotions and other behaviors. CTE is a very controversial condition that is still not well-understood. Researchers do not yet know the frequency of CTE in the population and do not understand the causes. There is no cure for CTE.

The endocrine system is a network of glands that produce and release hormones that help control many important body functions, including the body’s ability to change calories into energy that powers cells and organs. The endocrine system is a network of glands that produce and release hormones that help control many important body functions, including the body’s ability to change calories into energy that powers cells and organs. The endocrine system influences how your heart beats, how your bones and tissues grow, even your ability to make a baby. It plays a vital role in whether or not you develop diabetes, thyroid disease, growth disorders, sexual dysfunction, and a host of other hormone-related disorders.

Endometriosis is a problem affecting a woman’s uterus. Endometriosis occurs when the kind of tissue that normally lines the uterus grows somewhere else. It can grow on the ovaries, behind the uterus or on the bowels or bladder. Rarely, it grows in other parts of the body. This “misplaced” tissue can cause pain, infertility, and very heavy periods. The pain is usually in the abdomen, lower back or pelvic areas. Some women have no symptoms at all. Having trouble getting pregnant may be the first sign.

Eosinophilic esophagitis (EoE) is a newly recognized chronic disease that can be associated with food allergies. It is increasingly being diagnosed in children and adults. EoE is characterized by inflammation and accumulation of a specific type of immune cell, called an eosinophil, in the esophagus. Eosinophils are a type of white blood cell. They help fight off infections and play a role in your body’s immune response. They can also build up and cause inflammation. Normally your blood doesn’t have a large number of eosinophils. Your body may produce more of them in response to, allergic disorders, skin conditions, parasitic and fungal infection, autoimmune diseases, some cancers, and bone marrow disorders. In some conditions, the eosinophils can move outside the bloodstream and build up in organs and tissues. Symptoms of EoE include nausea, vomiting, and abdominal pain after eating. A person may also have symptoms that resemble acid reflux from the stomach. In older children and adults, it can cause more severe symptoms, such as difficulty swallowing solid food or solid food sticking in the esophagus for more than a few minutes. In infants, this disease may be associated with failure to thrive. In some situations, avoiding certain food allergens will be an effective treatment for EoE.

Eosinophilic fasciitis is a very rare syndrome in which muscle tissue under the skin, called fascia, becomes swollen and thick. The hands, arms, legs, and feet can swell quickly. The disease may look similar to scleroderma but is not related. The cause of eosinophilic fasciitis is unknown. In people with this condition, white blood cells called eosinophils, build up in the muscles and tissues. Eosinophils are linked to allergic reactions. The syndrome is more common in people ages 30 to 60. Symptoms can include: bone pain or tenderness, carpal tunnel syndrome, muscle weakness, tenderness and swelling of the arms, legs and sometimes the joints, and thickened skin that looks puckered. In most cases, the condition goes away within 3 to 5 years. However, symptoms may last longer or come back.

Erectile dysfunction (impotence) is the inability to get and keep an erection firm enough for sex. Having erection trouble from time to time isn’t necessarily a cause for concern. If erectile dysfunction is an ongoing issue, however, it can cause stress, affect your self-confidence and contribute to relationship problems. Problems getting or keeping an erection can also be a sign of an underlying health condition that needs treatment and a risk factor for heart disease.

Erythema nodosum is an inflammatory disorder that involves tender, red bumps (nodules) under the skin. In about half of cases, the exact cause of erythema nodosum is unknown. Some cases may occur with infections. Some of the more common infections are: streptococcus (most common), cat scratch disease, chlamydia, coccidioidomycosis, hepatitis B, histoplasmosis, leptospirosis, mononucleosis (EBV), mycobacteria, mycoplasma, psittacosis, syphilis, tuberculosis, tularemia, and yersinia. Erythema nodosum may occur with sensitivity to certain medications, including: antibiotics including amoxicillin and other penicillins, sulfonamides, sulfones, birth control pills, and progestin. Erythema nodosum is most common on the shins. It may also occur on other areas of the body such as buttocks, calves, ankles, thighs, and arms. The lesions begin as flat, firm, hot, red, painful lumps that are about an inch across. Within a few days, they may become purplish in color. Over several weeks, the lumps fade to a brownish, flat patch.

Essential mixed cryoglobulinemia is often found in people who have a chronic (long-lasting) inflammatory condition, such as an autoimmune disease or hepatitis C. Most people with mixed cryoglobulinemia have a chronic hepatitis C infection. Cryoglobulins are antibodies. It is not yet known why they become solid or gel-like at low temperatures. When this occurs, these antibodies can block blood vessels. This may lead to problems ranging from skin rashes to kidney failure. Cryoglobulinemia is the presence of these abnormal proteins in the blood. Although the underlying mechanisms have not been fully elucidated, cryoglobulin formation is clearly linked to the attempt of the host to clear the significant quantities of virions generated daily by the chronic infection. Other conditions that may be related to cryoglobulinemia include: leukemia, multiple myeloma, mycoplasma pneumonia, primary macroglobulinemia, rheumatoid arthritis, and systemic lupus erythematosus. Symptoms will vary depending on the type of disorder you have and the organs that are involved. Symptoms may include: breathing problems, fatigue, glomerulonephritis, joint pain, muscle pain, purpura, raynaud’s phenomenon, skin death, and skin ulcers.

Evans syndrome is a very rare autoimmune disorder in which the immune system destroys the body’s red blood cells, white blood cells and/or platelets. Affected people often experience thrombocytopenia (too few platelets) and Coombs’ positive hemolytic anemia (premature destruction of red blood cells). Signs and symptoms may include purpura, paleness, fatigue, and light-headedness. The exact cause of this condition is unknown. The best treatment options for Evans syndrome depend on many factors, including the severity of the condition, the signs and symptoms present, and each person’s response to certain therapies.

Any disease of the cornea. Macular Degeneration, eye disease caused by degeneration of the cells of the macula lutea and results in blurred vision; can cause blindness. Retinopathy, disease of the retina that can result in loss of vision.

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Facioscapulohumeral (FSHD). Muscle weakness typically begins in the face and shoulders. The shoulder blades might stick out like wings when a person with FSHD raises his or her arms. Onset usually occurs in the teenage years but may begin in childhood or as late as age 40.

Fibromyalgia is a chronic disorder which is characterized by widespread pain, tenderness and fatigue. Persons with fibromyalgia may also experience sleep disturbances, morning stiffness, anxiety, and irritable bowel syndrome. Often it is also accompanied by depression. It is difficult to diagnose because most of the symptoms mimic those of other disorders. Fibromyalgia is NOT an autoimmune disease, however it does accompany other autoimmune rheumatic and endocrine diseases.

Fibrosing alveolitis, also known as Idiopathic pulmonary fibrosis (IPF), involves scarring or thickening of the lungs. Doctors do not know what causes idiopathic pulmonary fibrosis (IPF) or why some people get it. Idiopathic means the cause is not known. The condition may be due to the lungs and autoimmune system responding to an unknown substance or injury. Genes may play a role in developing IPF. The disease occurs most often in people between 50 and 70 years old. When you have IPF, your lungs become scarred and stiffened. This makes it hard for you to breathe. In some people, IPF gets worse quickly over months or a few years. In others, IPF worsens over a much longer time. Symptoms can include chest pain (occasionally), cough (usually dry), decreased tolerance for activity, and shortness of breath during activity (this symptom lasts for months or years, and over time may also occur when at rest). There is no known cure for IPF. Treatment is aimed at relieving symptoms.

Forearm tendonitis is inflammation of the tendons of the forearm. The forearm is the part of your arm between the wrist and the elbow. Tendons are soft bands of connective tissue that attach muscles to bones and allow joints to flex and extend. When tendons are irritated or injured, they become inflamed. That causes tendonitis.

Forearm tendonitis is inflammation of the tendons of the forearm. The forearm is the part of your arm between the wrist and the elbow. Tendons are soft bands of connective tissue that attach muscles to bones and allow joints to flex and extend. When tendons are irritated or injured, they become inflamed. That causes tendonitis.

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Giant cell arteritis (temporal arteritis) is a disorder that causes inflammation of arteries of the scalp, neck, and arms. It narrows the arteries, which keeps blood from flowing well. Giant cell arteritis often occurs with another autoimmune disorder called polymyalgia rheumatica. Both are more common in women than in men and almost always affect people over the age of 50. Early symptoms of giant cell arteritis resemble the flu: fatigue, loss of appetite, and fever. Other symptoms include headaches, pain and tenderness over the temples, double vision or visual loss, dizziness, problems with coordination and balance, as well as pain in your jaw and tongue.

Giant cell myocarditis is a disease of relatively young, predominantly healthy adults. The patients usually die of heart failure and ventricular arrhythmia unless a cardiac transplantation is performed. The term myocarditis refers to an autoimmune inflammatory response within the myocardium that is not secondary to ischemic events or cardiac rejection in the setting of transplantation. The incidence of giant cell myocarditis is low and it varies with the population which is being studied and the method of diagnosis which is used. In a Japanese autopsy registry, the incidence of giant cell myocarditis was 0.007%. There is no proven cure because of the unknown nature of the disorder.

Glaucoma is a group of eye conditions that damage the optic nerve, which is vital to good vision. This damage is often caused by an abnormally high pressure in your eye. Glaucoma is one of the leading causes of blindness in the United States. It can occur at any age but is more common in older adults. The most common form of glaucoma has no warning signs. The effect is so gradual that you may not notice a change in vision until the condition is at an advanced stage. Vision loss due to glaucoma can’t be recovered. So it’s important to have regular eye exams that include measurements of your eye pressure. If glaucoma is recognized early, vision loss can be slowed or prevented.

Glomerulonephritis is a type of kidney disease in which the part of your kidneys that helps filter waste and fluids from the blood is damaged. Glomerulonephritis may be caused by problems with the body’s immune system. Often, the exact cause of glomerulonephritis is unknown. Damage to the glomeruli causes blood and protein to be lost in the urine. The condition may develop quickly, and kidney function is lost within weeks or months (called rapidly progressive glomerulonephritis). A quarter of people with chronic glomerulonephritis have no history of kidney disease. The following may increase your risk of this condition: blood or lymphatic system disorders, exposure to hydrocarbon solvents, history of cancer, infections such as strep, viruses, heart infections, abscesses, amyloidosis, anti-glomerular basement membrane antibody disease, goodpasture syndrome, heavy use of pain relievers, especially NSAIDs, henoch-schonlein purpura, IgA nephropathy, lupus nephritis, and membranoproliferative GN. Common symptoms of glomerulonephritis include: blood in the urine (dark, rust-colored, or brown urine), foamy urine (due to excess protein in the urine), and swelling (edema) of the face, eyes, ankles, feet, legs, or abdomen.

Goodpasture’s syndrome is a pulmonary-renal syndrome, which is a group of acute illnesses involving the kidneys and lungs. Goodpasture syndrome includes all of the following conditions: * Glomerulonephritis – inflammation of the glomeruli, which are tiny clusters of looping blood vessels in the kidneys that help filter wastes and extra water from the blood. * The presence of anti-glomerular basement membrane (GBM) antibodies; the GBM is part of the glomeruli and is composed of collagen and other proteins. * Bleeding in the lungs.

Graft versus host disease (GvHD) is a condition that might occur after an allogeneic transplant. In GvHD, the donated bone marrow or adult peripheral blood stem cells view the recipient’s body as foreign, and the donated cells/bone marrow attack the body. This has not been found to occur with Cord Blood Stem Cells.

A grand mal seizure causes a loss of consciousness and violent muscle contractions. It’s the type of seizure most people picture when they think about seizures. A grand mal seizure — also known as a generalized tonic-clonic seizure — is caused by abnormal electrical activity throughout the brain. Usually, a grand mal seizure is caused by epilepsy. But sometimes, this type of seizure can be triggered by other health problems, such as extremely low blood sugar, a high fever or a stroke. Many people who have a grand mal seizure never have another one and don’t need treatment. But someone who has recurrent seizures may need treatment with daily anti-seizure medications to control and prevent future grand mal seizures.

Granulomatosis with Polyangiitis (GPA) (formerly called Wegener’s Granulomatosis) is a rare autoimmune disease in which blood vessels and other tissues become inflamed. This inflammation limits blood flow to important organs in the body, potentially leading to long-term damage. Disease onset and severity varies among patients, and earlier diagnosis and treatment can prevent life-threatening organ failure. Although the disease can involve any organ system, GPA mainly affects the respiratory tract (sinuses, nose, trachea [windpipe], and lungs) and kidneys. This disorder can affect people at any age and strikes men and women equally. Compared to other racial groups, Caucasians are more commonly affected. The most common sign of GPA is upper respiratory tract distress such as sinus pain, discolored or bloody fluid from the nose, and nasal ulcers. A common sign of the disease is a constant runny nose or other cold symptoms that do not respond to usual treatment or become increasingly worse.

Graves’ disease is an autoimmune thyroid disease which causes the thyroid gland to produce excessive hormones. Symptoms may include nervousness, weight loss, heart palpitations and intolerance to heat. Women are affected seven times more often than men and are predominantly diagnosed between 20-40 years of age. A distinguishing characteristic of Graves’ is an eye condition causing inflamed eye muscles with accompanying bulging of the eyes (exophthalmos). Approximately 30-50% of Graves’ patients develop this condition in its mild form and about 5% develop the severe form. Although rare, “thyroid storm” can occur. Symptoms of this thyroid crisis include fever, vomiting, elevated heart rate, confusion and profuse sweating and requires immediate emergency attention.

Guillain-Barre syndrome is a rare autoimmune disorder that causes your immune system to attack your peripheral nervous system (PNS). The PNS nerves connect your brain and spinal cord with the rest of your body. Damage to these nerves makes it hard for them to transmit signals. As a result, your muscles have trouble responding to your brain. No one knows what causes the syndrome. Sometimes it is triggered by an infection, surgery, or a vaccination. The first symptom is usually weakness or a tingling feeling in your legs. The feeling can spread to your upper body. In severe cases, you become almost paralyzed. This is life-threatening. You might need a respirator to breathe. Symptoms usually worsen over a period of weeks and then stabilize. Recovery can take a few weeks to a few years.

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Hair loss can affect just your scalp or your entire body. It can be the result of heredity, hormonal changes, medical conditions or medications. Anyone can experience hair loss, but it’s more common in men. Baldness typically refers to excessive hair loss from your scalp. Hereditary hair loss with age is the most common cause of baldness. Some people prefer to let their hair loss run its course untreated and unhidden. Others may cover it up with hairstyles, makeup, hats or scarves. And still others choose one of the treatments available to prevent further hair loss and to restore growth.

The human hands are complex and delicate structures that contain 27 bones. The muscles and joints in the hand allow for strong, precise, and dexterous movements, but they are vulnerable to injury. There are many different causes and types of hand pain. Hand pain can originate in different parts of the complex skeletal structure, including the: bones joints connective tissues tendons nerves Hand pain can stem from: inflammation nerve damage repetitive motion injuries sprains and fractures several chronic health conditions Many conditions contributing to hand pain can be treated. Depending on the cause of your hand pain, you may benefit from medications, exercises, or lifestyle changes. 1. Arthritis 2. Carpal tunnel syndrome 3. De Quervain’s tenosynovitis 4. Ganglion cysts 5. Gout 6. Lupus 7. Peripheral neuropathy 8. Raynaud’s phenomenon 9. Stenosing tenosynovitis 10. Traumatic injury

Hashimoto’s thyroiditis is a chronic inflammatory autoimmune thyroid disease in which the immune system attacks and destroys the thyroid gland. The thyroid then produces too little hormone and metabolism is slowed. It is the most common of all the thyroid conditions in the US and women are affected 10 times more often than men. Most diagnoses occur between the ages of 30-50 and prevalence increases with age in both women and men. Symptoms, which often develop gradually, may include weight gain, cold sensitivity, tingling in the hands and feet, fatigue, hair loss, dry hair, fertility problems, and difficulty concentrating. Thyroid hormone should be monitored in women who plan pregnancy. Low thyroid function can affect the development of the baby. Post-partum thyroiditis can develop in the 12 months following childbirth. Women who are having trouble conceiving should also have their thyroid levels checked as thyroid hormone levels can affect ovulation.

Hearing loss, also known as hearing impairment, is a partial or total inability to hear. A deaf person has little to no hearing. Hearing loss may occur in one or both ears. Hearing loss is diagnosed when hearing testing finds that a person is unable to hear 25 decibels in at least one ear.

Cardiovascular disease generally refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke. Other heart conditions, such as those that affect your heart’s muscle, valves or rhythm, also are considered forms of heart disease.

A heart attack is a life-threatening condition that occurs when blood flow to the heart muscle is abruptly cut off, causing tissue damage. This is usually the result of a blockage in one or more of the coronary arteries.

Myocardial infarction (MI): The damaging or death of an area of the heart muscle (myocardium) resulting from a blocked blood supply to that area. It’s also the medical term for a heart attack. Coronary thrombosis: Formation of a clot in one of the arteries that supply blood to the heart muscle.

Hemolytic anemia autoimmune hemolytic anemia is an autoimmune disorder which causes the premature destruction of red blood cells. A normal red blood cell has a lifespan of approximately 120 days before the spleen removes it from circulation. Red blood cells are made in the bone marrow and released into circulation. In persons with autoimmune hemolytic anemia, the red blood cells are destroyed prematurely; and bone marrow production of new cells cannot make up for their loss. The severity of this disorder is determined by the length of time the red blood cell survives and by the capability of the bone marrow to continue red blood cell production.

Henoch-Schonlein purpura (HSP) is a fairly common autoimmune childhood disorder that may affect adults as well, although less frequently. Children with this condition are often initially seen with acute abdominal pain and are referred for surgical evaluation. HSP is characterized by purpura, or allergy=related bleeding into the skin and other tissues. The characteristic palpable purpuric rash is found in the majority of cases and is considered the hallmark of the disease. This rash is most often located on the buttocks and upper thighs in children and on the feet and ankles in adults. Symptoms also occurring with HSP are joint pain, gastrointestinal disorders and kidney involvement. Less common manifestations include peripheral neuropathy and testicular torsion.

Autoimmune hepatitis is a chronic inflammatory autoimmune disease of the liver. It usually occurs by itself, but it can coexist with other autoimmune diseases. The male/female ratio is 8:1, and it most often occurs in persons of Northern European extraction. It is usually classified as Type I or Type II. Type I is the most common and occurs at any age, most commonly in women. Type II is less common, affecting mostly girls between the ages of two to fourteen, although adults can have it too.

Hepatitis B is a serious liver infection caused by the hepatitis B virus (HBV). For some people, hepatitis B infection becomes chronic, meaning it lasts more than six months. Having chronic hepatitis B increases your risk of developing liver failure, liver cancer or cirrhosis — a condition that permanently scars of the liver. Most adults with hepatitis B recover fully, even if their signs and symptoms are severe. Infants and children are more likely to develop a chronic (long-lasting) hepatitis B infection. A vaccine can prevent hepatitis B, but there’s no cure if you have the condition. If you’re infected, taking certain precautions can help prevent spreading the virus to others.

Hepatitis C is a viral infection that causes liver inflammation, sometimes leading to serious liver damage. The hepatitis C virus (HCV) spreads through contaminated blood. Until recently, hepatitis C treatment required weekly injections and oral medications that many HCV-infected people couldn’t take because of other health problems or unacceptable side effects.

Herpes gestationis or pemphigoid gestationis (PG) is a bullous (characterized by blistering, such as a second-degree burn) disease developing in association with pregnancy. It is believed to be an autoimmune disorder. It occurs during pregnancy, typically in the second or third trimester, and/or immediately following pregnancy. It was originally called herpes gestationis because of the blistering appearance, although it is not associated with the herpes virus. Diagnosis of PG becomes clear when skin lesions progress to tense blisters during the second or third trimester. PG typically starts as a blistering rash in the navel area and then spreads over the entire body. It is sometimes accompanied by raised, hot, painful welts called plaques. After one to two weeks, large, tense blisters typically develop on the red plaques, containing clear or blood-stained fluid. PG creates a histamine (compound involved in local immune responses) response that causes extreme relentless itching (pruritus). PG is characterized by flaring and remission during the gestational and sometimes post partum period. Usually after delivery, lesions will heal within months, but may reoccur during menstruation.

Hidradenitis suppurativa (HS) is a disease that usually begins as pimple-like bumps on the skin. The pimple-like bumps tend to develop in places that everyday pimples do not appear. HS is most common on the underarms and groin.

Also known as degenerative joint disease or age-related arthritis, osteoarthritis is more likely to develop as people get older. Osteoarthritis occurs when inflammation and injury to a joint cause a breaking down of cartilage tissue. It causes pain and swelling in the body’s joints, such as the knees or hips.

Hip replacement surgery is a procedure in which a doctor surgically removes a painful hip joint with arthritis and replaces it with an artificial joint often made from metal and plastic components. It usually is done when all other treatment options have failed to provide adequate pain relief. The procedure should relieve a painful hip joint, making walking easier.

Hives — also known as urticaria (ur-tih-KAR-e-uh) — is a skin reaction that causes itchy welts, which can range in size from small spots to large blotches several inches in diameter. Hives can be triggered by exposure to certain foods, medications or other substances. Angioedema is a related type of swelling that affects deeper layers in your skin, often around your face and lips. In most cases, hives and angioedema are harmless and don’t leave any lasting marks, even without treatment. The most common treatment for hives and angioedema is antihistamine medication. Serious angioedema can be life-threatening if swelling causes your throat or tongue to block your airway.

High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease. Blood pressure is determined both by the amount of blood your heart pumps and the amount of resistance to blood flow in your arteries. The more blood your heart pumps and the narrower your arteries, the higher your blood pressure. You can have high blood pressure (hypertension) for years without any symptoms. Even without symptoms, damage to blood vessels and your heart continues and can be detected. Uncontrolled high blood pressure increases your risk of serious health problems, including heart attack and stroke. High blood pressure generally develops over many years, and it affects nearly everyone eventually. Fortunately, high blood pressure can be easily detected.

The retina is the tissue layer located in the back of your eye. … Over time, high blood pressure can cause damage to the retina’s blood vessels, limit the retina’s function, and put pressure on the optic nerve, causing vision problems. This condition is called hypertensive retinopathy (HR).

Hypogammalglobulinemia is a type of primary immune deficiency disease. The common clinical feature of hypogammaglobulinemia relates to a predisposition toward infections that normally are defended against by antibody responses (including Streptococcus pneumoniae and Haemophilus influenzae infections).

Male hypogonadism is a condition in which the body doesn’t produce enough testosterone — the hormone that plays a key role in masculine growth and development during puberty — or has an impaired ability to produce sperm or both. You may be born with male hypogonadism, or it can develop later in life, often from injury or infection. The effects — and what you can do about them — depend on the cause and at what point in your life male hypogonadism occurs. Some types of male hypogonadism can be treated with testosterone replacement therapy.

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IgA nephropathy is an autoimmune related kidney disorder that occurs when IgA (a protein that helps the body fight infections) settles in the kidneys. After many years, the IgA deposits may cause the kidneys to leak blood and sometimes protein in the urine.This leakage does not necessarily mean they will have long-term problems. If too much protein leaks into the urine, the hands and feet can swell. After 10 to 20 years with IgA nephropathy, the kidneys may show signs of damage. About 25 percent of adults with IgA nephropathy develop total kidney failure. Only 5 to 10 percent of children develop total kidney failure. Symptoms of kidney failure include swelling in the hands and feet, nausea, fatigue, headaches, and sleep problems. By the time these symptoms occur, total kidney failure is near. Total kidney failure means the kidney damage is permanent. People with kidney failure need dialysis or a kidney transplant. IgA nephropathy can occur at any age, even in childhood. More men are affected than women. Although found all over the world, IgA nephropathy is more common among Caucasians and Asians. It is one of the most common diseases of the kidney, other than those caused by diabetes or high blood pressure.

IgG4-related sclerosing disease , also known as IgG4–related systemic disease (IgG4-RSD), hyper-IgG4 disease and IgG4-related disease is an autoimmune disease in which inflammatory cells cause fibrosis, the deposition of connective tissue, in one or more organs. The disease is so named because the antibody subtype IgG4 can be detected on tissue samples and often at elevated levels in the bloodstream. The association with IgG4 is a relatively recent finding, and the condition has been described under numerous other names in the past.

Immune thrombocytopenic purpura, (ITP) is an autoimmune bleeding disorder. The immune system destroys platelets, which are necessary for normal blood clotting. Persons with the disease have too few platelets in the blood. ITP is sometimes called immune thrombocytopenic purpura or simply, immune thrombocytopenia. ITP occurs when certain immune system cells produce antibodies against platelets. Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels. The antibodies attach to the platelets. The spleen destroys the platelets that carry the antibodies. In children, the disease sometimes follows a viral infection. In adults, it is more often a chronic (long-term) disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder. ITP affects women more often than men, and is more common in children than adults. The disease affects boys and girls equally. Symptoms can include any of the following: abnormally heavy menstruation, bleeding into the skin, often around the shins, causing a skin rash that looks like pinpoint red spots (petechial rash), easy bruising, nosebleed or bleeding in the mouth.

Inclusion body myositis (IBM) is one of a group of autoimmune related muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness. The onset of muscle weakness in IBM is generally gradual (over months or years) and affects both proximal (close to the trunk of the body) and distal (further away from the trunk) muscles. Muscle weakness may affect only one side of the body. Falling and tripping are usually the first noticeable symptoms of IBM. For some individuals, the disorder begins with weakness in the wrists and fingers that causes difficulty with pinching, buttoning, and gripping objects. There may be weakness of the wrist and finger muscles and atrophy (thinning or loss of muscle bulk) of the forearm muscles and quadricep muscles in the legs. Difficulty swallowing occurs in approximately half of IBM cases. Symptoms of the disease usually begin after the age of 50, although the disease can occur earlier. IBM occurs more frequently in men than in women. There is no cure for IBM.

Inflammatory arthritis is a term used to describe a group of conditions which affect your immune system. This means that your body’s defence system starts attacking your own tissues instead of germs, viruses and other foreign substances, which can cause pain, stiffness and joint damage.

Inflammation is a process by which the body’s white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses. However, in some diseases, like arthritis, the body’s defense system — the immune system — triggers an inflammatory response when there are no foreign invaders to fight off. In these diseases, called autoimmune diseases, the body’s normally protective immune system causes damage to its own tissues. The body responds as if normal tissues are infected or somehow abnormal. Some, but not all, types of arthritis are the result of misdirected inflammation. Arthritis is a general term that describes inflammation in the joints. Some types of arthritis associated with inflammation include the following: • Rheumatoid arthritis • Psoriatic arthritis • Gouty arthritis Other painful conditions of the joints and musculoskeletal system that may not be associated with inflammation include osteoarthritis, fibromyalgia, muscular low back pain, and muscular neck pain.

Autoimmune inner ear disease (AIED) is an unusual form of progressive non-age-related sensorineural hearing loss and sometimes vertigo. It occurs in both ears with cochlear and vestibular symptoms that progress over a period of weeks to months and affects hearing, and often balance function, in both ears. The classic presentation is with bilateral fluctuating but progressive sensorineural hearing loss leading on to severe deafness. Tinnitus (ringing, tinkling, buzzing, or other sounds in the ear) and intra-aural pressure may occur, as well as dizziness or vertigo.

Interstitial cystitis (IC) is an autoimmune related condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. It is far more common in women than in men. The symptoms vary from person to person. Some people may have pain without urgency or frequency. Others have urgency and frequency without pain. Women’s symptoms often get worse during their periods. They may also have pain with sexual intercourse. The cause of IC isn’t known. There is no one test to tell if you have it. Doctors often run tests to rule out other possible causes of symptoms. There is no cure for IC, but treatments can help most people feel better.

Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Signs and symptoms include cramping, abdominal pain, bloating, gas, and diarrhea or constipation, or both. IBS is a chronic condition that you’ll need to manage long term. Only a small number of people with IBS have severe signs and symptoms. Some people can control their symptoms by managing diet, lifestyle and stress. More-severe symptoms can be treated with medication and counseling. IBS doesn’t cause changes in bowel tissue or increase your risk of colorectal cancer.

Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Signs and symptoms include cramping, abdominal pain, bloating, gas, and diarrhea or constipation, or both. IBS is a chronic condition that you’ll need to manage long term. Only a small number of people with IBS have severe signs and symptoms. Some people can control their symptoms by managing diet, lifestyle and stress. More-severe symptoms can be treated with medication and counseling. IBS doesn’t cause changes in bowel tissue or increase your risk of colorectal cancer.

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A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including * Arthritis – inflammation of a joint. It causes pain, stiffness, and swelling. Over time, the joint can become severely damaged. * Bursitis – inflammation of a fluid-filled sac that cushions the joint * Dislocations – injuries that force the ends of the bones out of position

Definition of jumper’s knee. : a painful condition of the knee caused by inflammation or small tears in the tendon of the patella that occurs especially in sports requiring strenuous jumping.

Juvenile arthritis is a type of arthritis that happens in children age 16 or younger. It causes joint swelling, pain, stiffness, and loss of motion. It can affect any joint, and in some cases it can affect internal organs as well. One early sign of JA may be limping in the morning. Symptoms can come and go. Some children have just one or two flare-ups. Others have symptoms that never go away. JA causes growth problems in some children. No one knows exactly what causes JA. Scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body’s own tissues. JA can be hard to diagnose. Your health care provider may do a physical exam, lab tests, and x-rays. Medicines and physical therapy can help maintain movement and reduce swelling and pain.

Juvenile diabetes (Type 1 diabetes) can occur at any age. It is most often diagnosed in children, adolescents, or young adults. Insulin is a hormone produced in the pancreas by special cells called beta cells. The pancreas is below and behind the stomach. Insulin is needed to move blood sugar (glucose) into cells. Inside the cells, glucose is stored and later used for energy. With type 1 diabetes, beta cells produce little or no insulin. Without enough insulin, glucose builds up in the bloodstream instead of going into the cells. This buildup of glucose in the blood is called hyperglycemia. The body is unable to use the glucose for energy. This leads to the symptoms of type 1 diabetes. The exact cause of type 1 diabetes is unknown. Most likely it is an autoimmune disorder. This is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. With type 1 diabetes, an infection or another trigger causes the body to mistakenly attack the cells in the pancreas that make insulin. The tendency to develop autoimmune diseases, including type 1 diabetes, can be passed down through families.

Juvenile myositis (JM), including Juvenile Dermatomyositis (JDM) and Juvenile Polymyositis (JPM), is a group of rare and life-threatening autoimmune diseases, in which the body’s immune system attacks its own cells and tissues. Myositis means inflammation of the muscles that you use to move your body. It typically affects children ages 2 to 15 years, with symptoms that include weakness of the muscles close to the trunk of the body, inflammation, edema, muscle pain, fatigue, skin rashes, abdominal pain, fever, and contractures. Children with juvenile dermatomyositis may have difficulty swallowing and breathing, and the heart may also be affected. About 20 to 30 percent of children with juvenile dermatomyositis develop calcium deposits in the soft tissue. Muscle weakness without a rash is the primary symptom of Juvenile Polymyositis. Although medications can help alleviate the symptoms of JM, the disease has no known cure.

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Kawasaki disease is a rare form of vasculitis. Children, usually under the age of 5, have a high fever and red eyes, lips, mouth, a rash and swollen lymph nodes. The disease also affects the heart and the wall of blood vessels. Kawasaki is the leading cause of acquired heart disease in children. Immediate treatment is necessary to avoid permanent damage to the heart and to the coronary arteries and a full recovery may be expected.

Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine.

A cartilage defect is an area of damaged cartilage. Cartilage defects are most commonly seen in the knee joint, where it is often caused by trauma and seen in association with ligament injuries, such as ACL tears.

If you have cracking or popping that does cause pain or swelling, though, see a doctor. It can be a sign of: * Meniscus tears. The meniscus is a rubbery C-shaped disc that cushions your knee and acts as a shock-absorber. It also helps spread weight evenly so your bones don’t rub together. Tears to the meniscus are often caused by sudden twisting or other things you might do while playing sports. In young people, tears usually happen during a traumatic event, but as we age the meniscus can tear more easily. * Cartilage injury or wear. Sometimes the cartilage covering of our bones can be injured, causing a piece to break off and catch in our joint. Typically the knee will respond to this injury by swelling or catching. Cartilage in your knee can also wear thin or break down, commonly known as arthritis. Some people say it feels like their knees are grinding when they move. Osteoarthritis is the most common kind of arthritis. It usually affects middle-aged and older people.

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Lambert-Eaton syndrome is an autoimmune disorder in which faulty communication between nerves and muscles leads to muscle weakness. In this syndrome, substances produced by the immune system attack nerve cells. This makes nerves cells unable to release enough of a chemical called acetylcholine. This chemical transmits impulses between nerves and muscles. The result is muscle weakness. Lambert-Eaton syndrome may occur with cancers such as small cell lung cancer or autoimmune disorders such as vitiligo, which leads to a loss of skin pigment. Symptoms may include: weakness or loss of movement that can be more or less severe, difficulty chewing, difficulty climbing stairs, difficulty lifting objects, difficulty talking, drooping head, need to use hands to get up from sitting or lying positions, swallowing difficulty, gagging, or choking. Vision changes can occur such as: blurry vision, double vision, and problems keeping a steady gaze. The symptoms of Lambert-Eaton syndrome may improve by treating the underlying disease, suppressing the immune system, or removing the antibodies. However, not everyone responds well to treatment.

The lateral collateral ligament (LCL) is the ligament located in the knee joint. Ligaments are thick, strong bands of tissue that connect bone to bone. An injury to the LCL could include straining, spraining, and partially or completely tearing any part of that ligament.

Leber’s hereditary optic neuropathy (LHON) or Leber hereditary optic atrophy is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; this affects predominantly young adult males.

Leukocytoclastic vasculitis, also called hypersensitivity vasculitis, describes inflammation of small blood vessels. The term leukocytoclastic refers to the debris of neutrophils (immune cells) within the blood vessel walls. The disease can be confined to the skin (cutaneous) or it can affect many different organs of the body such as the kidneys, central nervous system, heart, gastrointestinal tract, and lungs. An allergic reaction to drugs, food, or food additives supports the theory of the immune system playing the dominant role. Infections, inflammatory bowel disease, rheumatoid arthritis, lupus erythematosus, Sjögren syndrome, and less often malignancy are some of the various conditions associated with the vasculitis. In the skin, damaged blood vessels become leaky and small areas of hemorrhage appear as purple-red, raised lesions known as palpable purpura. Multiple discrete or grouped lesions are commonly found on the legs or other dependent areas of the body. These lesions are usually asymptomatic but can be itchy or painful. Signs of systemic involvement include fever, muscle aches, joint pain, blood in the urine or stool, abdominal pain, vomiting, cough, numbness, and weakness.

Lichen planus is a condition that forms an itchy rash on the skin or in the mouth. The exact cause of lichen planus is unknown. It may be related to an allergic or immune reaction. Risks for the condition include: exposure to medicines, dyes, and other chemicals (including gold, antibiotics, arsenic, iodides, chloroquine, quinacrine, quinide, phenothiazines, and diuretics), and diseases such as hepatitis C. Lichen planus mostly affects middle-aged adults. It is less common in children. Symptoms you may see include mouth sores that will sometimes form painful ulcers, skin sores that are itchy and have even sides (symmetrical) and sharp borders, dry mouth, hair loss, metallic taste in the mouth, and ridges in the nails (nail abnormalities). A skin lesion biopsy or biopsy of a mouth lesion can confirm the diagnosis. Blood tests may be done to rule out hepatitis. Lichen planus is usually not harmful. It usually gets better with treatment. The condition often clears up within 18 months but may come and go for years. If lichen planus is caused by a medicine you are taking, the rash should go away once you stop the medicine.

Lichen sclerosus is a skin disorder that can affect men, women, or children, but is most common in women. It usually occurs on the vulva (the outer genitalia or sex organ) in women, but sometimes develops on the head of the penis in men. Occasionally, lichen sclerosus is seen on other parts of the body, especially the upper body, breasts, and upper arms. Other names for lichen sclerosus include kraurosis vulvae and hypoplastic dystrophy. Doctors think a too active immune system and hormone problems may play a role in the cause of lichen sclerosus. It is also thought that people inherit the likelihood of getting the disease. Sometimes, lichen sclerosus appears on skin that has been damaged or scarred from some other previous injury. Early in the disease, small white spots appear on the skin. The spots are usually shiny and smooth. Later, the spots grow into bigger patches. The skin on the patches becomes thin and crinkled. Then the skin tears easily, and bright red or purple bruises are common. Sometimes, the skin becomes scarred. If the disease is a mild case, there may be no symptoms.

Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.

Limbal stem cell deficiency (LSCD) is characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus. When these stem cells are lost, the corneal epithelium is unable to repair and renew itself.

Limb-girdle. Hip and shoulder muscles are usually the first affected. People with this type of muscular dystrophy may have difficulty lifting the front part of the foot and as a result may trip frequently. Onset usually begins in childhood or the teenage years.

Linear IgA Disease is a rare skin blistering condition. This condition affects the skin and mucosal (inside the mouth and/or genitalia) surfaces of the body.

Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood. Liver disease includes the following conditions: * Cirrhosis, or scarring of the liver * Inflammation (hepatitis) from infectious (hepatitis B, hepatitis C) or non-infectious causes (chemical or autoimmune hepatitis) * Tumors, benign and malignant (liver cancer) * Metabolic disorders

Lliotibial band syndrome is one of the leading causes of lateral knee pain in runners. The iliotibial band is a thick band of fascia on the lateral aspect of the knee, extending from the outside of the pelvis, over the hip and knee, and inserting just below the knee.

An early symptom of tetanus characterized by spasm of the jaw muscles and inability to open the jaws.

Amyotrophic lateral sclerosis or ALS, is a progressive nervous system (neurological) disease that destroys nerve cells and causes disability. ALS is often called Lou Gehrig’s disease, after the famous baseball player who was diagnosed with it. ALS is a type of motor neuron disease in which nerve cells gradually break down and die. Doctors usually don’t know why ALS occurs. Some cases are inherited. ALS often begins with muscle twitching and weakness in a limb, or slurred speech. Eventually, ALS affects control of the muscles needed to move, speak, eat and breathe.

Degenerative disc disease in the lumbar spine, or lower back, refers to a syndrome in which age-related wear and tear on a spinal disc causes low back pain. See Causes of Lower Back Pain. Save. When damaged discs in the lumbar spine cause symptoms of pain, it is called lumbar degenerative disc disease.

Spinal cord injury: Trauma or damage to the spinal cord, the major column of nerve tissue that is connected to the brain and lies within the vertebral canal and from which the spinal nerves emerge. The spinal cord and the brain constitute the central nervous system. The spinal cord consists of nerve fibers that transmit impulses to and from the brain. Like the brain, the spinal cord is covered by three connective-tissue envelopes called the meninges. The space between the outer and middle envelopes is filled with cerebrospinal fluid (CSF), a clear colorless fluid that cushions the spinal cord against jarring shock. The spinal cord is very sensitive to injury. Unlike other parts of your body, the spinal cord does not have the ability to repair itself if it is damaged. A spinal cord injury occurs when there is damage to the spinal cord either from trauma, loss of its normal blood supply, or compression from tumor or infection.

Lung disease is any problem in the lungs that prevents the lungs from working properly. There are three main types of lung disease: Airway diseases — These diseases affect the tubes (airways) that carry oxygen and other gases into and out of the lungs. They usually cause a narrowing or blockage of the airways.

Lupus is a chronic inflammatory autoimmune disease. There are three common types of lupus. Systemic Lupus Erythematosus (SLE) is the most serious. SLE can affect almost any organ or system in the body including blood vessels, muscles, joints, the digestive tract, lungs, kidneys, heart and central nervous system. * Discoid lupus causes a raised, scaly, red rash, usually on the face, scalp and neck and may cause scarring. * Drug-induced lupus is a type of lupus which is caused by prescription medications. Symptoms are similar to those of SLE; and once the medication is stopped, the symptoms usually cease. * Neonatal lupus is a rare disease that can affect some newborn babies of women with SLE or certain other immune system disorders. These babies may have a heart defect, skin rash, low blood count, and/or liver problems. However, most infants of mothers with SLE are born healthy.

Juvenile myositis (JM), including Juvenile Dermatomyositis (JDM) and Juvenile Polymyositis (JPM), is a group of rare and life-threatening autoimmune diseases, in which the body’s immune system attacks its own cells and tissues. Myositis means inflammation of the muscles that you use to move your body. It typically affects children ages 2 to 15 years, with symptoms that include weakness of the muscles close to the trunk of the body, inflammation, edema, muscle pain, fatigue, skin rashes, abdominal pain, fever, and contractures. Children with juvenile dermatomyositis may have difficulty swallowing and breathing, and the heart may also be affected. About 20 to 30 percent of children with juvenile dermatomyositis develop calcium deposits in the soft tissue. Muscle weakness without a rash is the primary symptom of Juvenile Polymyositis. Although medications can help alleviate the symptoms of JM, the disease has no known cure.

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A degenerative condition affecting the central part of the retina (the macula) and resulting in distortion or loss of central vision. It occurs especially in older adults, in which case it is called age-related macular degeneration.

The definition of urinary incontinence in men is the unintentional loss of urine. Weak or damaged bladder muscles, overactive bladder muscles, certain prostate conditions, and nerve damage are just some of the possible underlying causes of urinary incontinence in men.

Stem cells are undifferentiated cells that are capable of renewal and repair of tissue due to their capacity for division and differentiation. Recent advances in the use of stem cell (SC) therapy for male erectile dysfunction (ED) show Four clinical trials employing SC for ED showed improvements in ED after SC therapy.

The medial collateral ligament (MCL) is located on the inner aspect, or part, of your knee, but it’s outside the joint itself. Ligaments hold bones together and add stability and strength to a joint. The MCL connects the top of the tibia, or shinbone, to the bottom of the femur, or thighbone. An injury to the MCL is often called an MCL sprain. Ligament injuries can either stretch the ligament or tear it. MCL injury of the knee is usually caused by a direct blow to the knee. This type of injury is common in contact sports. It’s usually the result of a hit or blow to the outer aspect of the knee, which stretches or tears the MCL.

Shin splints, also known as medial tibial stress syndrome (MTSS), is defined by the American Academy of Orthopaedic Surgeons as “pain along the inner edge of the shinbone. (tibia).” Shin splints are usually caused by repeated trauma to the connective muscle tissue surrounding the tibia.

Meniere’s disease is a disorder of the inner ear. It can cause severe dizziness, a roaring sound in your ears called tinnitus, hearing loss that comes and goes and the feeling of ear pressure or pain. It usually affects just one ear. It is a common cause of hearing loss. Attacks of dizziness may come on suddenly or after a short period of tinnitus or muffled hearing. Some people have single attacks of dizziness once in a while. Others may have many attacks close together over several days. Some people with Meniere’s disease have “drop attacks” during which the dizziness is so bad they lose their balance and fall. Scientists don’t yet know the cause. They think that it has to do with the fluid levels or the mixing of fluids in the canals of your inner ear. Doctors diagnose it based on a physical exam and your symptoms. A hearing test can check to see how it has affected your hearing. There is no cure. Treatments include medicines to control dizziness, limiting salt in your diet, and taking water pills. A device that fits into the outer ear and delivers air pulses to the middle ear can help. Severe cases may require surgery.

Meningitis is a rare infection that affects the delicate membranes — called meninges — that cover the brain and spinal cord. You or your children can catch it. There are several types of this disease, including bacterial, viral, and fungal. Bacterial meningitis can be life-threatening and spreads between people in close contact with each other. Viral meningitis tends to be less severe, and most people recover completely without treatment. Fungal meningitis is a rare form of the disease. It usually only happens in people who have a weakened immune system — the body’s defense against germs.

A torn meniscus is one of the most common knee injuries. Any activity that causes you to forcefully twist or rotate your knee, especially when putting your full weight on it, can lead to a torn meniscus. Each of your knees has two menisci — C-shaped pieces of cartilage that act like a cushion between your shinbone and your thighbone. A torn meniscus causes pain, swelling and stiffness. You also might feel a block to knee motion and have trouble extending your knee fully.

Metatarsalgia (met-uh-tahr-SAL-juh) is a condition in which the ball of your foot becomes painful and inflamed. You might develop it if you participate in activities that involve running and jumping. There are other causes as well, including foot deformities and shoes that are too tight or too loose. Although generally not serious, metatarsalgia can sideline you. Fortunately, at-home treatments, such as ice and rest, often relieve symptoms. Wearing proper footwear with shock-absorbing insoles or arch supports might prevent or minimize future problems with metatarsalgia.

Microscopic polyangiitis (MPA) is an autoimmune related disorder that causes blood vessel inflammation (vasculitis), which can lead to organ damage. The kidneys, lungs, nerves, skin, and joints are the most commonly affected areas of the body. MPA is diagnosed in people of all ages, all ethnicities, and both genders. The cause of this disorder is unknown.

A migraine can cause severe throbbing pain or a pulsing sensation, usually on just one side of the head. It’s often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Migraine attacks can cause significant pain for hours to days and can be so severe that the pain is disabling. Warning symptoms known as aura may occur before or with the headache. These can include flashes of light, blind spots, or tingling on one side of the face or in your arm or leg.

Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud’s phenomenon; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications may help manage the symptoms.

Monomelic amyotrophy (MMA) is characterized by progressive degeneration and loss of motor neurons, the nerve cells in the brain and spinal cord that are responsible for controlling voluntary muscles. It is characterized by weakness and wasting in a single limb, usually an arm and hand rather than a foot and leg. There is no pain associated with MMA. While some physicians contend that mild sensory loss may be associated with this disease, many experts suggest that such symptoms actually indicate a cause other than MMA. MMA occurs in males between the ages of 15 and 25. Onset and progression are slow. MMA is seen most frequently in Asia, particularly in Japan and India; it is much less common in North America. In most cases, the cause is unknown, although there have been a few published reports linking MMA to traumatic or radiation injury.

Mooren’s ulcer is a rare disease that studies suggest is an autoimmune disorder. Some cases run a chronic severe course and fail to respond to local and systemic therapy. Mooren’s ulcer is an idiopathic (unknown origin) noninfectious ulceration (The process or fact of being eroded away, as by an ulcer) of the peripheral cornea that has been classified into 2 clinical types. One is a milder, unilateral, less progressive form of the disease generally seen in elderly patients that responds well to therapy. The second type is a much more aggressive, frequently bilateral, relentless disease usually seen in younger patients that is poorly responsive to any therapy and often leads to corneal destruction.

A motor neuron disease (MND) is any of several neurodegenerative disorders that selectively affect motor neurons, the cells that control voluntary muscles of the body.[2] Motor neuron diseases include: * Amyotrophic lateral sclerosis (ALS) * Hereditary spastic paraplegia (HSP) * Primary lateral sclerosis (PLS) * Progressive muscular atrophy (PMA) * Progressive bulbar palsy (PBP) * Pseudobulbar palsy

Mucha-Habermann disease may also be called PLEVA (pityriasis lichenoides et varioliformisacuta). It is a skin disease characterized by a recurrent red rash that is itchy and burning. There are red elevated areas on the skin, with small pus, lymph, or serous-filled blister-like elevations. There also may be headache, chills, malaise, and sometime pain in one or more joints. It affects females and males equally.

Multifocal motor neuropathy (MMN) or multifocal motor neuropathy with conduction block (MMNCB) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy. Signs and symptoms include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; and atrophy of affected muscles. MMN is thought to be due to an abnormal immune response, but the underlying cause is not clear. Most people treated with intravenous immune globulin (IVIG) have rapid improvement in weakness, but maintenance IVIG is usually required for sustained improvement.

Toggle ContentMultiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of MS. They can include visual disturbances, muscle weakness, trouble with coordination and balance, sensations such as numbness, prickling, or “pins and needles”, and thinking and memory problems. No one knows what causes MS. It may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins between the ages of 20 and 40. Usually, the disease is mild, but some people lose the ability to write, speak, or walk. There is no single test for MS. Doctors use a medical history, physical exam, neurological exam, MRI, and other tests to diagnose it. There is no cure for MS, but medicines may slow it down and help control symptoms. Physical and occupational therapy may also help.

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a combination of symptoms that affect both the autonomic nervous system (the part of the nervous system that controls involuntary action such as blood pressure or digestion) and movement.

A muscle strain, or pulled muscle, occurs when your muscle is overstretched or torn. This usually occurs as a result of fatigue, overuse, or improper use of a muscle. Strains can happen in any muscle, but they’re most common in your lower back, neck, shoulder, and hamstring, which is the muscle behind your thigh. These strains can cause pain and may limit movement within the affected muscle group. Mild to moderate strains can be successfully treated at home with ice, heat, and anti-inflammatory medications. Severe strains or tears may require medical treatment.

Muscular dystrophy is a group of diseases that cause progressive weakness and loss of muscle mass. In muscular dystrophy, abnormal genes (mutations) interfere with the production of proteins needed to form healthy muscle. There are many different kinds of muscular dystrophy. Symptoms of the most common variety begin in childhood, mostly in boys. Other types don’t surface until adulthood. There’s no cure for muscular dystrophy. But medications and therapy can help manage symptoms and slow the course of the disease.

Myasthenia gravis is disease that causes weakness in the muscles under your control. It happens because of a problem in communication between your nerves and muscles. Myasthenia gravis is an autoimmune disease. Your body’s own immune system makes antibodies that block or change some of the nerve signals to your muscles. This makes your muscles weaker. Common symptoms are trouble with eye and eyelid movement, facial expression and swallowing. But it can also affect other muscles. The weakness gets worse with activity, and better with rest. There are medicines to help improve nerve-to-muscle messages and make muscles stronger. With treatment, the muscle weakness often gets much better. Other drugs keep your body from making so many abnormal antibodies. There are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. Sometimes surgery to take out the thymus gland helps. For some people, myasthenia gravis can go into remission and they do not need medicines. The remission can be temporary or permanent. If you have myasthenia gravis, it is important to follow your treatment plan. If you do, you can expect your life to be normal or close to it.

The term “myocardial infarction” focuses on the myocardium (the heart muscle) and the changes that occur in it due to the sudden deprivation of circulating blood. The main change is necrosis (death) of myocardial tissue. The word “infarction” comes from the Latin “infarcire” meaning “to plug up or cram.” It refers to the clogging of the artery.

Autoimmune heart diseases are the effects of the body’s own immune defense system mistaking cardiac antigens as foreign and attacking them leading to inflammation of the heart as a whole, or in parts. The commonest form of autoimmune heart disease is rheumatic heart disease or rheumatic fever.

Myositis means inflammation of the muscles that you use to move your body. An injury, infection, or autoimmune disease can cause it. Two specific kinds are polymyositis and dermatomyositis. Polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. Dermatomyositis causes muscle weakness, plus a skin rash. Other symptoms of myositis may include: fatigue after walking or standing, tripping or falling, trouble swallowing or breathing. Doctors may use a physical exam, lab tests, imaging tests and a muscle biopsy to diagnose myositis. There is no cure for these diseases, but you can treat the symptoms.

Also known as Steinert’s disease, this form is characterized by an inability to relax muscles at will following contractions. Myotonic muscular dystrophy is the most common form of adult-onset muscular dystrophy. Facial and neck muscles are usually the first to be affected.

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Narcolepsy is a chronic brain disorder that involves poor control of sleep-wake cycles. People with narcolepsy experience periods of extreme daytime sleepiness and sudden, irresistible bouts of sleep that can strike at any time. These “sleep attacks” usually last a few seconds to several minutes. Contrary to common beliefs, people with narcolepsy do not spend a substantially greater proportion of their time asleep during a 24-hour period than do normal sleepers. In addition to daytime drowsiness and uncontrollable sleep episodes, most individuals also experience poor sleep quality that can involve frequent waking during nighttime sleep, and other sleep disorders. Narcolepsy can greatly affect daily activities. People may unwillingly fall asleep while at work or at school, when having a conversation, playing a game, eating a meal, or, most dangerously, when driving or operating other types of machinery. Narcolepsy affects both males and female equally and appears throughout the world. Symptoms often start in childhood or adolescence, but can occur later in life. The condition is life-long. Narcolepsy cannot yet be cured, but some of the symptoms can be treated with medicines and lifestyle changes.

Clinical instability of the cervical spine is defined as the inability of the spine under physiological loads to maintain its normal pattern of displacement so that there is no neurological damage or irritation, no development of deformity, and no incapacitating pain.

Cervical disc: A disk shaped piece of specialized tissue that separates the vertebral bones of the spinal column in the neck. … When the disc has herniated or ruptured, it may create pressure against one or more of the spinal nerves which can cause pain, weakness or numbness in the neck and arm.

Cervical Osteoarthritis (Neck Arthritis). When this condition develops in the cervical spine, it is called cervical osteoarthritis. See Osteoarthritis of the Spine. Save. Cervical osteoarthritis is a degenerative condition that can cause neck pain and stiffness.

Neonatal lupus is an uncommon autoimmune disease manifested primarily by cutaneous lupus lesions and/or congenital heart block. Maternal autoantibodies of the Ro/La family are present in virtually every case, although only approximately 1% of women who have these autoantibodies will have a baby with neonatal lupus. The cutaneous lesions of neonatal lupus may be present at birth, but more often develop within the first few weeks of life. Lesions are most common on the face and scalp, often in a distinctive periorbital distribution. Lesions tend to resolve in a few weeks or months without scarring.

Neuromyelitis optica – formally known as Devic’s disease, Neuromyelitis optica (NMO) is an uncommon disease syndrome of the central nervous system (CNS) that affects the optic nerves and spinal cord. Individuals with NMO develop optic neuritis, which causes pain in the eye and vision loss, and transverse myelitis, which causes weakness, numbness, and sometimes paralysis of the arms and legs, along with sensory disturbances and loss of bladder and bowel control. NMO leads to loss of myelin, which is a fatty substance that surrounds nerve fibers and helps nerve signals move from cell to cell. The syndrome can also damage nerve fibers and leave areas of broken-down tissue. In the disease process of NMO, for reasons that aren’t yet clear, immune system cells and antibodies attack and destroy myelin cells in the optic nerves and the spinal cord.

Neuropathy, a result of damage to your peripheral nerves, often causes weakness, numbness and pain, usually in your hands and feet. It can also affect other areas of your body. Your peripheral nervous system sends information from your brain and spinal cord (central nervous system) to the rest of your body. Peripheral neuropathy can result from traumatic injuries, infections, metabolic problems, inherited causes and exposure to toxins. One of the most common causes is diabetes mellitus. People with peripheral neuropathy generally describe the pain as stabbing, burning or tingling. In many cases, symptoms improve, especially if caused by a treatable condition. Medications can reduce the pain of peripheral neuropathy.

Neuropathy, a result of damage to your peripheral nerves, often causes weakness, numbness and pain, usually in your hands and feet. It can also affect other areas of your body. Your peripheral nervous system sends information from your brain and spinal cord (central nervous system) to the rest of your body. Peripheral neuropathy can result from traumatic injuries, infections, metabolic problems, inherited causes and exposure to toxins. One of the most common causes is diabetes mellitus. People with peripheral neuropathy generally describe the pain as stabbing, burning or tingling. In many cases, symptoms improve, especially if caused by a treatable condition. Medications can reduce the pain of peripheral neuropathy.

Neutropenia is an abnormally low number of white blood cells. These cells, which are called neutrophils, help the body fight infection. White blood cells are produced in the bone marrow. They are released into the bloodstream, and travel wherever they are needed. Low levels of neutrophils occur when the bone marrow cannot replace them as fast as needed. A very severe infection may cause neutrophils to be used up quickly, and may also prevent the bone marrow from producing more neutrophils. In rare cases, mothers may have antibodies against their baby’s neutrophils. These antibodies cross the placenta before birth and cause the baby’s cells to break down (autoimmune neutropenia). In other rare cases, a problem with the baby’s bone marrow may lead to decreased white blood cell production. In many cases, neutropenia goes away on its own as the bone marrow recovers and begins to produce enough white blood cells.

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Obesity means having far too much body fat. It’s about much more than your clothing size or how you look. It can seriously affect your health. Your whole body feels it, from your joints to your heart, blood pressure, blood sugar, and other systems. The extra fat cells produce inflammation and various hormones, which boosts your odds of chronic medical conditions.

Ocular cicatricial pemphigoid is a rare, chronic, blistering and scarring disease that affects the oral and ocular mucosa. Other mucosal sites that might be affected include the nasopharnyx, larynx, genitalia, rectum, and esophagus. The condition usually begins in late adulthood (e.g. 50’s or 60’s), affects more women than men, and has a variable prognosis. Scarring of the affected mucosa of the eye may lead to blindness and tends to be the most feared complication. A combination of environmental and genetic factors appear to play a role in the susceptibility of developing cicatricial pemphigoid. Although the specific causes of this condition have not been identified, it is considered an autoimmune disease that is characterized by the production of autoantibodies.

Oculopharyngeal muscular dystrophy (OPMD) is a rare genetic muscle disorder with onset during adulthood most often between 40 and 60 years of age. OPMD is characterized by slowly progressive muscle disease (myopathy) affecting the muscles of the upper eyelids and the throat.

Autoimmune oophoritis is an autoimmune inflammation of ovaries resulting in their destruction, atrophy, and fibrosis with a loss of fertility and ovary hormonal production. These changes stop the ovaries from working normally.

Optic neuritis is inflammation of the optic nerve, caused by damage to and loss of the protective sheath (myelin) surrounding this nerve that is so vital for good vision.

Optic neuritis is inflammation of the optic nerve. It may cause sudden, reduced vision in the affected eye. The exact cause of optic neuritis is unknown. The optic nerve carries visual information from your eye to the brain. Sudden inflammation of this nerve can cause the optic nerve to swell. This can result in injury to the nerve fibers and some or permanent loss of vision. Conditions that have been linked with optic neuritis include: autoimmune diseases, including lupus, sarcoidosis, Behcet’s disease, and more. Symptoms include loss of vision in one eye over an hour or a few hours, changes in the way the pupil reacts to bright light, loss of color vision, and pain when you move the eye. Vision often returns to normal within 2 to 3 weeks with no treatment. People who have optic neuritis without a disease such as multiple sclerosis have a good chance of recovery.

Autoimmune orchitis is characterized by testis inflammation and the presence of specific antisperm antibodies (ASA). It is classified in two categories. Primary autoimmune orchitis is defined by infertility and asymptomatic orchitis associated with ASA (100%) directed to the basement membrane or seminiferous tubules in infertile men, without any systemic disease and usually asymptomatic. Secondary autoimmune orchitis is characterized by symptomatic orchitis and/or testicular vasculiti`s associated with a systemic autoimmune disease, particularly vasculitis. These patients typically demonstrate testicular pain, erythema and/or swelling. ASA in secondary autoimmune orchitis have been reported in up to 50% of patients, especially in systemic lupus erythematosus patients.

Disorders are ailments, injuries or diseases that cause knee problems, whiplash, dislocated shoulder, torn cartilages, foot pain and fibromyalgia. There are as many treatments for orthopedic disorders as there are problems and injuries in the muscles, ligaments and joints.

Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage on the ends of your bones wears down over time. Although osteoarthritis can damage any joint in your body, the disorder most commonly affects joints in your hands, knees, hips and spine. Osteoarthritis symptoms can usually be effectively managed, although the underlying process cannot be reversed. Staying active, maintaining a healthy weight and other treatments may slow progression of the disease and help improve pain and joint function.

Osteochondrosis is a self-limiting developmental derangement of normal bone growth, primarily involving the centers of ossification in the epiphysis. [1, 2] It usually begins in childhood as a degenerative or necrotic condition. By definition, osteochondrosis is an aseptic ischemic necrosis.

Osteophytes is a term referring to bone spurs, smooth structures that form on the spine over a long period of time. Bone spurs are physical indications that there is degeneration in the spine and become common with age.

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Palindromic rheumatism (PR) is an autoimmune related disease characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. Each episode may last from several hours to several days. The frequency of attacks also varies, from one episode a day to several during the course of a year. Between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. The cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. There may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. Some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis.

PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus). This term is used to describe a subset of children who have Obsessive Compulsive Disorder (OCD) and/or tic disorders such as Tourette Syndrome, and in whom symptoms worsen following strep infections such as “Strep throat” and Scarlet Fever. The children usually have dramatic, “overnight” onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions. In addition to these symptoms, children may also become moody, irritable or show concerns about separating from parents or loved ones. This abrupt onset is generally preceded by a Strep throat infection. Researchers at the NIMH are pursuing a theory that the mechanism or cause is similar to that of Rheumatic Fever, an autoimmune disorder triggered by strep throat infections. PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus).

Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to an underlying (usually undetected) malignant tumor. Patients with paraneoplastic neurological syndrome (PNS) most often present with neurologic symptoms before an underlying tumor is detected. Paraneoplastic neurologic syndromes include many neurologic disorders including paraneoplastic cerebellar degeneration (PCD) caused by an immune-mediated mechanism other than a metastatic complication in patients with an underlying malignancy. Any part of the nervous system can be involved depending on the type of primary malignancy.

Parkinson’s disease is a progressive nervous system disorder that affects movement. Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. Tremors are common, but the disorder also commonly causes stiffness or slowing of movement. In the early stages of Parkinson’s disease, your face may show little or no expression. Your arms may not swing when you walk. Your speech may become soft or slurred. Parkinson’s disease symptoms worsen as your condition progresses over time.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease in which red blood cells break down earlier than normal. Persons with this disease have blood cells that are missing a gene called PIG-A. This gene allows a substance called glycosyl-phosphatidylinositol (GPI) to help certain proteins stick to cells. Without PIG-A, important proteins cannot connect to the cell surface and protect the cell from substances in the blood called complement. As a result, red blood cells break down too early. The red cells leak hemoglobin into the blood, which can pass into the urine. This can happen at any time, but is more likely to occur during the night or early morning. The disease can affect people of any age. It may be associated with aplastic anemia, myelodysplastic syndrome, or acute myelogenous leukemia. Risk factors, except for prior aplastic anemia, are not known. The outcome varies. Most people survive for more than 10 years after their diagnosis. Death can result from complications such as blood clot formation (thrombosis) or bleeding. In rare cases, the abnormal cells may decrease over time.

Parry Romberg syndrome is a rare disorder characterized by slowly progressive deterioration (atrophy) of the skin and soft tissues of half of the face (hemifacial atrophy), usually the left side. An autoimmune mechanism is suspected, and the syndrome may be a variant of localized scleroderma. It is more common in females than in males. Initial facial changes usually involve the tissues above the upper jaw (maxilla) or between the nose and the upper corner of the lip (nasolabial fold) and subsequently progress to the angle of the mouth, areas around the eye, the brow, the ear, and the neck. The deterioration may also affect the tongue, the soft and fleshy part of the roof of the mouth, and the gums. The eye and cheek of the affected side may become sunken and facial hair may turn white and fall out (alopecia). In addition, the skin overlying affected areas may become darkly pigmented (hyperpigmentation) with, in some cases, areas of hyperpigmentation and patches of unpigmented skin (vitiligo). Parry-Romberg syndrome is also accompanied by neurological abnormalities including seizures and episodes of severe facial pain (trigeminal neuralgia). The onset of the disease usually begins between the ages of 5 and 15 years. The progression of the atrophy often lasts from 2 to 10 years, and then the process seems to enter a stable phase. Muscles in the face may atrophy and there may be bone loss in the facial bones. Problems with the retina and optic nerve may occur when the disease surrounds the eye. There is no cure and there are no treatments that can stop the progression of Parry-Romberg syndrome. In mild cases, the disorder usually causes no disability other than cosmetic effects.

Pars planitis (peripheral uveitis) is a disease of the eye in which there is inflammation of the pars plana, a small area of tissue next to the iris that is responsible for making aqueous humor (the fluid in the eye that nourishes the lens and cornea). Pars planitis is often referred to as intermediate uveitis because the pars plana is a part of the uvea. This condition most often affects young men and is generally not associated with any other disease or symptoms (idiopathic). However, there have been a few case reports of an association with autoimmune disease such as Crohn’s disease. Some experts also suggest a possible association with multiple sclerosis, sarcoidosis, cat scratch or Lyme disease.

Parsonage-Turner syndrome, also called brachial neuritis, is characterized by the sudden onset of shoulder and upper arm pain followed by marked upper arm weakness or atrophy. Individuals may present with the condition several weeks after an injury, infection or immunization, or in the absence of an obvious inciting event. Treatment is symptomatic and may include pain relievers and physical therapy. Although affected individuals may experience paralysis of the affected areas that lasts for months or even years, the prognosis is generally favorable with most individuals experiencing complete recovery within 2 years.

Pemphigus is a group of chronic autoimmune skin diseases characterized by blister formations in the outer layer of the skin and the mucous membranes. Pemphigus vulgaris begins with blister formations (bullae) in the mouth or on the scalp. The blisters are soft and easily broken. The blistering can also affect the esophagus, rectum, nose or the lining of the eyelids. These bullae heal without scarring. Pemphigus vulgaris most often occurs in middle-aged patients of Jewish or Mediterranean descent. It has been associated with other autoimmune diseases such as myasthenia gravis and lupus. Diagnosis of an autoimmune bullous disease should be suspect when: * there is no clear history of exposure to a drug or a contact allergen * when other studies for infectious origins, such as herpes or impetigo, are negative To differentiate these diseases, a careful history and physical examination are important. A skin biopsy is often helpful.

Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, first part of the small intestine or sometimes the lower esophagus. An ulcer in the stomach is known as a gastric ulcer while that in the first part of the intestines is known as a duodenal ulcer.

Peripheral artery disease (also called peripheral arterial disease) is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs. When you develop peripheral artery disease (PAD), your extremities — usually your legs — don’t receive enough blood flow to keep up with demand.

Peripheral neuropathy – More than 100 types of peripheral neuropathy have been identified, each with its own symptoms and prognosis. In general, peripheral neuropathies are classified according to the type of damage to the nerves. Some forms of neuropathy involve damage to only one nerve and are called mononeuropathies. More frequently however, multiple nerves are affected, called polyneuropathy. An estimated 20 million people in the United States have some form of peripheral neuropathy, a condition that develops as a result of damage to the peripheral nervous system — the vast communications network that transmits information between the central nervous system (the brain and spinal cord) and every other part of the body. (Neuropathy means nerve disease or damage.) Autoimmune diseases, in which the immune system attacks the body’s own tissues, can lead to nerve damage. Sjogren’s syndrome, lupus, and rheumatoid arthritis are among the autoimmune diseases that can be associated with peripheral neuropathy. Symptoms can range from numbness or tingling, to pricking sensations (paresthesia), or muscle weakness. Areas of the body may become abnormally sensitive leading to an exaggeratedly intense or distorted experience of touch (allodynia). In such cases, pain may occur in response to a stimulus that does not normally provoke pain. Severe symptoms may include burning pain (especially at night), muscle wasting, paralysis, or organ or gland dysfunction. Most people recover from this autoimmune syndrome although severe cases can be life threatening. In the most extreme cases, breathing may become difficult, or organ failure may occur.

Peripheral vascular disease (PVD) is a blood circulation disorder that causes the blood vessels outside of your heart and brain to narrow, block, or spasm. This can happen in your arteries or veins. PVD typically causes pain and fatigue, often in your legs, and especially during exercise.

Perivenous encephalomyelitis – Perivenous demyelination is the pathological hallmark of acute disseminated encephalomyelitis. Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers. ADEM is thought to be an autoimmune disorder and often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella. The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma. ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking). ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar. However, ADEM has several features which differentiate it from MS. Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children. In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. The long-term prognosis for individuals with ADEM is generally favorable. For most individuals, recovery begins within days, and within six months the majority of ADEM patients will have total or near total recoveries. Others may have mild to moderate lifelong impairment ranging from cognitive difficulties, weakness, loss of vision, or numbness. Severe cases of ADEM can be fatal but this is a very rare occurrence.

Pernicious anemia (PA) is a decrease in red blood cells that occurs when the intestines cannot properly absorb vitamin B12. Red blood cells provide oxygen to body tissues. There are many types of anemia. Pernicious anemia is a type of vitamin B12 anemia. The body needs vitamin B12 to make red blood cells. You get this vitamin from eating foods such as meat, poultry, shellfish, eggs, and dairy products. A special protein, called intrinsic factor (IF), helps your intestines absorb vitamin B12. This protein is released by cells in the stomach. When the stomach does not make enough intrinsic factor, the intestine cannot properly absorb vitamin B12. Common causes of pernicious anemia include: weakened stomach lining (atrophic gastritis), an autoimmune condition in which the body’s immune system attacks the actual intrinsic factor protein or the cells in the lining of your stomach that make it. Very rarely, pernicious anemia is passed down through families. This is called congenital pernicious anemia. Babies with this type of anemia do not make enough intrinsic factor. Or they cannot properly absorb vitamin B12 in the small intestine. In adults, symptoms of pernicious anemia are usually not seen until after age 30. The average age of diagnosis is age 60. Patients usually do well with treatment. It is important to start treatment early. Nerve damage can be permanent if treatment does not start within 6 months of symptoms.

Peyronie’s disease is a disorder in which scar tissue, called a plaque, forms in the penis—the male organ used for urination and sex. The plaque builds up inside the tissues of a thick, elastic membrane called the tunica albuginea.

Pick’s disease is a specific pathology that is one of the causes of frontotemporal lobar degeneration. It is also known as Pick disease and PiD (not to be confused with pelvic inflammatory disease (PID) or Parkinson’s disease.

Piriformis syndrome is an uncommon neuromuscular disorder that is caused when the piriformis muscle compresses the sciatic nerve. It passes alongside or goes through the piriformis muscle, goes down the back of the leg, and eventually branches off into smaller nerves that end in the feet.

Plantar fasciitis (PLAN-tur fas-e-I-tis) is one of the most common causes of heel pain. It involves inflammation of a thick band of tissue that runs across the bottom of your foot and connects your heel bone to your toes (plantar fascia).

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) – POEMS syndrome is a rare autoimmune related blood disorder that damages your nerves and affects many other parts of the body. POEMS syndrome can be misdiagnosed because the signs and symptoms mimic those of other disorders. POEMS syndrome progresses rapidly and may become life-threatening, so early diagnosis is important. POEMS stands for these signs and symptoms: Polyneuropathy. Numbness, tingling and weakness in your legs — and over time, maybe in your hands — and difficulty breathing. Organomegaly. Enlarged spleen, liver or lymph nodes. Endocrinopathy. Abnormal hormone levels that can result in underactive thyroid (hypothyroidism), diabetes, sexual problems, fatigue, swelling in your limbs, and problems with metabolism and other essential functions. Monoclonal plasma-proliferative disorder. Abnormal bone marrow cells (plasma cells) that produce a protein (monoclonal protein) that can be found in the bloodstream. Skin changes. More color than normal on your skin, possibly thicker skin and increased facial or leg hair.

Polyarteritis nodosa is a serious autoimmune related blood vessel disease. The small and medium-sized arteries become swollen and damaged. Arteries are the blood vessels that carry oxygen-rich blood to organs and tissues. The cause of polyarteritis nodosa is unknown. The condition occurs when certain immune cells attack the affected arteries. More adults than children get this disease. The tissues that are fed by the affected arteries do not get the oxygen and nourishment they need. Damage occurs as a result. People with active hepatitis B or hepatitis C may develop this disease. Symptoms are caused by damage to affected organs. The skin, joints, muscle, gastrointestinal tract, heart, kidneys, and nervous system are often affected. Symptoms include: abdominal pain, decreased appetite, fatigue, fever, joint aches, muscle aches, unintentional weight loss, and weakness. If nerves are affected, you may have numbness, pain, burning, and weakness. Damage to the nervous system may cause strokes or seizures. Current treatments with steroids and other drugs that suppress the immune system can improve symptoms and the chance of long-term survival. The most serious complications usually involve the kidneys and gastrointestinal tract.

Relapsing polychondritis is a rare autoimmune rheumatic disorder characterized by episodes of painful, destructive inflammation of the cartilage and other connective tissues in many organs. The ears or nose may become inflamed and tender.

Polyglandular syndromes type I, II, III (PDS) is characterized by sequential or simultaneous deficiencies in the function of several endocrine glands that have a common cause. Etiology (cause, set of causes) is most often autoimmune. Polyglandular deficiency syndromes (PDS) involve deficiencies in the function of several endocrine glands, which may occur simultaneously or sequentially. Nonendocrine organs also may be affected. Most cases are autoimmune; triggers are often unknown but may involve viruses or dietary substances. PDS is distinguished by the glands affected. Categorization depends on the combination of deficiencies, which fall within 1of 3 types. Diagnosis requires measurement of hormone levels and autoantibodies against affected endocrine glands. Treatment includes replacement of missing or deficient hormones and sometimes immunosuppressants. Risk factors for the development of autoimmunity include Genetic factors and Environmental triggers. Genetic factors include the AIRE gene mutation, which is causative of type 1, and certain HLA subtypes, which are important in the development of types 2 and 3. Environmental triggers include viral infections, dietary factors, and other as yet unknown exposures.

Polymyalgia rheumatica is characterized by muscle pain and stiffness in the neck, shoulder, and hip area. This stiffness, lasting about 30 minutes, is more severe upon waking or after a period of inactivity. Persons also may have “flu-like” symptoms. The symptoms may come on suddenly or gradually and usually strikes people over 50 years of age with age 70 the most common age of onset. There may be remission in one to several years. Up to 15% of persons develop giant cell arteritis (also called temporal arteritis), during or after polymyalgia symptoms appear.

Polymyositis is a rare inflammatory disease that leads to muscle weakness, swelling tenderness, and tissue damage. It is part of a larger group of diseases called myositis. Polymyositis affects the skeletal muscles. It is also known as idiopathic inflammatory myopathy. The exact cause is unknown, but it may be related to an autoimmune reaction or infection. Polymyositis can affect people at any age. It most common in adults between ages 50 and 70, and in children ages 5 to 15. It affects women twice as often as men. It is more common in African Americans than Caucasians. Polymyositis is a systemic disease, which means it affects the whole body. Muscle weakness and tenderness can be signs of polymyositis. Response to treatment varies based on the complications. The 5-year mortality rate can be as high as 1 in 5 patients. Many people, especially children, have a period when no symptoms are present and recover. For most other people, immunosuppressant drugs can control the disease.

Medical Definition of polyradiculoneuropathy. : an inflammatory disorder (as Guillain-Barré syndrome) affecting peripheral nerves and the nerve roots of the spinal nerves and marked by demyelination or axon degeneration.

Post refers to treatment after an event. Myocardial infarction (MI) refers to tissue death (infarction) of the heart muscle (myocardium). It is a type of acute coronary syndrome, which describes a sudden or short-term change in symptoms related to blood flow to the heart. However, an MI may lead to heart failure.

Postmyocardial infarction syndrome: Dressler’s syndrome is a type of pericarditis, inflammation of the sac surrounding the heart (pericardium). Inflammation associated with Dressler’s syndrome is believed to be an immune system response following damage to heart tissue or the pericardium, such as a heart attack, surgery or traumatic injury. Dressler’s syndrome symptoms include chest pain, much like that experienced during a heart attack, and fever. With recent improvements in heart attack treatment, Dressler’s syndrome is less common than it used to be. However, once you’ve had this condition, it may happen again. Dressler’s syndrome may also be called postpericardiotomy, post-myocardial infarction syndrome, and post-cardiac injury syndrome. Symptoms are likely to appear weeks to months after a heart attack, surgery or other heart injury.

Postpericardiotomy syndrome – a frequent complication of open-heart surgery, is characterized by fever, chest pain, and pericardial and pleural effusions. These signs may develop 1 to 12 weeks after intracardiac surgery in approximately 30 percent of patients. Although the etiology of the syndrome is unknown, evidence points to a viral and/or autoimmune cause. Postpericardiotomy syndrome is diagnosed after excluding other conditions such as endocarditis and pneumonia. In many cases, the syndrome is self-limiting and occurs only once, but in other cases the symptoms have recurred as many as eight times. Early recognition of the syndrome is the key to limiting the discomfort and possible complications associated with this condition.

Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. OI describes a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position.

Pressure ulcers, also known as pressure sores, decubitus ulcers, and bedsores, and now referred to as pressure injuries are localized damage to the skin and/or underlying tissue that usually occur over a bony prominence as a result of pressure or pressure in combination with shear and/or friction.

Primary biliary cirrhosis is irritation and swelling (inflammation) of the bile ducts of the liver. This blocks the flow of bile, which damages the liver cells and leads to scarring called cirrhosis. The cause of inflamed bile ducts in the liver is not known. However, primary biliary cirrhosis is an autoimmune disorder. That means your body’s immune system mistakenly attacks healthy tissue. The disease more commonly affects middle-aged women. Long-term bile obstruction is believed to lead to liver cirrhosis. The disease may be linked to autoimmune disorders such as: celiac disease, Raynaud’s phenomenon, sicca syndrome (dry eyes or mouth), and thyroid disease. More than half of patients have no symptoms at the time of diagnosis. Symptoms most often come on slowly and may include: abdominal pain, enlarged liver, fatigue, fatty deposits under the skin, fatty stools, itching, jaundice, and soft yellow spots on the eyelid. The outcome can vary. If the condition is not treated, most patients will die without a liver transplant. About a quarter of patients who have had the disease for 10 years will have liver failure. Doctors can now use a statistical model to predict the best time to do the transplant. Other diseases such as hypothyroidism and anemia can also develop.

Primary sclerosing cholangitis refers to swelling (inflammation), scarring, and destruction of the bile ducts inside and outside of the liver. The cause of this condition is usually unknown. The disease may be seen in patients who have: autoimmune disorders, chronic pancreatitis, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), and sarcoidosis. Genetic factors may also be responsible. Sclerosing cholangitis occurs more often in men than women. This disorder is rare in children. The first symptoms are usually: fatigue, itching, and yellowing of the skin and eyes (jaundice). However, some people may have no symptoms. How well patients do varies. The disease tends to get worse over time.

Progesterone dermatitis is a rare condition characterized by a cyclic skin rash which develops premenstrually in women. The condition usually occurs in adulthood after the start of periods (menarche), and rarely during pregnancy or postmenopause. Signs and symptoms vary among affected individuals; skin findings that have been reported include hives, erythema multiforme, papulovesicles (an eczema-like rash), annular erythema, angiodema, mouth erosions and pruritus (itching). The rash typically begins a few days before menses and subsides around the time menstruation begins, recurring at the next cycle. The exact cause is unknown, but is thought to involve a hypersensitivity or autoimmune reaction to a woman’s own progesterone. Depending on the severity, treatment may include topical medications, systemic corticosteroids, hormone therapy to inhibit the production of progesterone, or surgical removal of the ovaries.

Prostate problems facts* The prostate is a gland that is a part of the male reproductive system that wraps around the male urethra near the bladder. Common problems are benign prostatic hyperplasia (BPH), acute and chronic bacterial prostatitis, and chronic prostatitis (non-bacterial).

The PRP therapy improves the quality of your skin! Platelet-Rich Plasma (PRP) therapy, also known as a “vampire facelift”. The PRP-facelift is a non-surgical facelift for rejuvenating the skin. With this treatment you receive injections of your own blood.

Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. You usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. Some people who have psoriasis also get a form of arthritis called psoriatic arthritis. A problem with your immune system causes psoriasis. In a process called cell turnover, skin cells that grow deep in your skin rise to the surface. Normally, this takes a month. In psoriasis, it happens in just days because your cells rise too fast. Psoriasis can be hard to diagnose because it can look like other skin diseases. Your doctor might need to look at a small skin sample under a microscope. Psoriasis can last a long time, even a lifetime. Symptoms come and go. Things that make them worse include: infections, stress, dry skin, and certain medicines. Psoriasis usually occurs in adults. It sometimes runs in families. Treatments include creams, medicines, and light therapy.

Psoriatic arthritis – Some people with psoriasis have psoriatic arthritis. It causes pain, stiffness, and swelling of the joints. It is often mild, but can sometimes be serious and affect many joints. The joint and skin problems don’t always happen at the same time. Your doctor will do a physical exam and imaging tests to diagnose psoriatic arthritis. There is no cure, but medicines can help control inflammation and pain. In rare cases, you might need surgery to repair or replace damaged joints.

Pulmonary hypertension is a life-threatening condition that gets worse over time, but treatments can help your symptoms so you can live better with the disease. Having pulmonary arterial hypertension (PAH) means that you have high blood pressure in the arteries that go from your heart to your lungs.

Pulmonary fibrosis (literally “scarring of the lungs”) is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems.

Pure red cell aplasia (PRCA) is an uncommon disorder in which maturation (growth) arrest occurs in the formation of erythrocytes (red blood cells). Secondary PRCA occurs in patients with conditions such as autoimmune disorders, thymomas, systemic lupus erythematosus, hematologic malignancies, and solid tumors. The life expectancy of patients with idiopathic PRCA is about 1-2 decades. The survival of patients with congenital PRCA is limited. The lifespan of patients with secondary PRCA depends on the course of the underlying disorder.

Pyoderma gangrenosum is an uncommon, ulcerative cutaneous condition of uncertain etiology (cause). It is associated with systemic autoimmune related diseases in at least 50% of patients who are affected. The diagnosis is made by excluding other causes of similar-appearing cutaneous ulcerations, including infection, malignancy, vasculitis, collagen vascular diseases, diabetes, and trauma. In a process termed pathergy, new ulcerations may occur after trauma or injury to the skin in 30% of patients who already have pyoderma gangrenosum. The prognosis of pyoderma gangrenosum is generally good; however, the disease may recur, and residual scarring is common. Pain is a common complaint of patients and may require narcotics.

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Raynaud’s phenomenon is a condition in which cold temperatures or strong emotions cause blood vessel spasms. This blocks blood flow to the fingers, toes, ears, and nose. Raynaud’s phenomenon can be linked to other conditions. This is called secondary Raynaud’s phenomenon. Most people with the condition are over age 30. Common causes are:, diseases of the arteries (such as atherosclerosis and Buerger’s disease), drugs that cause narrowing of arteries (such as amphetamines, certain types of beta-blockers, some cancer drugs, certain drugs used for migraine headaches), arthritis and autoimmune conditions (such as scleroderma, Sjogren’s syndrome, rheumatoid arthritis, and systemic lupus erythematosus) , repeated injury or usage (such as from typing, playing the piano, or heavy use of hand tools), smoking, frostbite, and thoracic outlet syndrome. Raynaud’s phenomenon can also occur without another cause. This is called primary Raynaud’s phenomenon. It most often begins in people younger than age 30.

Reactive Arthritis is a form of autoimmune arthritis or joint inflammation, that occurs as a “reaction” to an infection elsewhere in the body. Inflammation is a characteristic reaction of tissues to injury or disease and is marked by swelling, redness, heat, and pain. Besides this joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. Reactive arthritis is a type of “spondyloarthritis” a group of disorders that can cause inflammation throughout the body, especially in the spine. (Examples of other disorders in this group include psoriatic arthritis, ankylosing spondylitis, and the kind of arthritis that sometimes accompanies inflammatory bowel disease.) In many patients, reactive arthritis is triggered by an infection in the bladder, the urethra, or, in women, the vagina (the urogenital tract) that is often transmitted through sexual contact. This form of the disorder is sometimes called genitourinary or urogenital reactive arthritis. Another form of reactive arthritis is caused by an infection in the intestinal tract from eating food or handling substances that are contaminated with bacteria. This form of arthritis is sometimes called enteric or gastrointestinal reactive arthritis. The symptoms of reactive arthritis usually last several months, although symptoms can return or develop into a long-term disease in a small percentage of people.

Reactive Arthritis is a form of autoimmune arthritis or joint inflammation, that occurs as a “reaction” to an infection elsewhere in the body. Inflammation is a characteristic reaction of tissues to injury or disease and is marked by swelling, redness, heat, and pain. Besides this joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. Reactive arthritis is a type of “spondyloarthritis” a group of disorders that can cause inflammation throughout the body, especially in the spine. (Examples of other disorders in this group include psoriatic arthritis, ankylosing spondylitis, and the kind of arthritis that sometimes accompanies inflammatory bowel disease.) In many patients, reactive arthritis is triggered by an infection in the bladder, the urethra, or, in women, the vagina (the urogenital tract) that is often transmitted through sexual contact. This form of the disorder is sometimes called genitourinary or urogenital reactive arthritis. Another form of reactive arthritis is caused by an infection in the intestinal tract from eating food or handling substances that are contaminated with bacteria. This form of arthritis is sometimes called enteric or gastrointestinal reactive arthritis. The symptoms of reactive arthritis usually last several months, although symptoms can return or develop into a long-term disease in a small percentage of people.

Reflex sympathetic dystrophy also called Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren’t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area. Because there is no cure for CRPS, treatment is aimed at relieving painful symptoms. The prognosis for CRPS varies from person to person. Spontaneous remission from symptoms occurs in certain individuals. Others can have unremitting pain and crippling, irreversible changes in spite of treatment.

Relapsing polychondritis is a rare disease in which cartilage in many areas of the body becomes inflamed. The disease most commonly affects the ears, nose and the airways of the lungs. The cause is not known, and it occurs most often in people in their 50s or 60s. One theory is that polychondritis might be an autoimmune disease, in which the immune system attacks the body rather than foreign invaders such as viruses. In polychondritis, it’s possible that a triggering event, perhaps an infection, sets off a reaction by the immune system, which unleashes an attack on the body’s cartilage. Some people may have a genetic makeup that makes them more prone to this. The disease does not seem to run in families. It sometimes appears in people who have other disease, such as rheumatoid arthritis, vasculitis (inflammation of blood vessels) and systemic lupus erythematosus (SLE or lupus). Polychondritis is a chronic (long-lasting) disease, although medications frequently can reduce the severity of symptoms. Sometimes, the disease goes into remission, meaning it goes away temporarily, whether or not the person is treated.

Renal artery stenosis (RAS) is the narrowing of one or both renal arteries. The renal arteries are blood vessels that carry blood to the kidneys from the aorta—the main blood vessel that carries blood from the heart to arteries throughout the body. Renovascular hypertension (RVH) is high blood pressure caused by RAS.

Restless legs syndrome (RLS) causes a powerful urge to move your legs. Your legs become uncomfortable when you are lying down or sitting. Some people describe it as a creeping, crawling, tingling, or burning sensation. Moving makes your legs feel better, but not for long. RLS can make it hard to fall asleep and stay asleep. In most cases, there is no known cause for RLS. In other cases, RLS is caused by a disease or condition, such as anemia or pregnancy. Some medicines can also cause temporary RLS. Caffeine, tobacco, and alcohol may make symptoms worse. Lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. If those don’t work, medicines may reduce the symptoms of RLS.

Retinal Degeneration: Macular degeneration is the leading cause of severe, irreversible vision loss in people over age 60. It occurs when the small central portion of the retina, known as the macula, deteriorates. The retina is the light-sensing nerve tissue at the back of the eye.

Autoimmune retinopathy (AIR) is a rare disease in which the patient’s immune system attacks proteins in the retina, leading to loss of eyesight. The condition is associated with retinal degeneration caused by autoimmune antibodies recognizing retinal proteins as antigens and targeting them.

Retroperitoneal fibrosis is a rare autoimmune related disorder that blocks the tubes (ureters) that carry urine from the kidneys to the bladder. Retroperitoneal fibrosis occurs when extra fibrous tissue forms in the area behind the stomach and intestines. The tissue forms a mass (or masses) that can block the tubes that carry urine from the kidney to the bladder. The cause of this problem is not known. It is most common in people aged 40 – 60. Men are twice as likely to develop the condition as women. Early symptoms include: dull pain in the abdomen that increases with time, pain and change of color in the legs (due to decreased blood flow), and swelling of one leg. Later symptoms include: decreased urine output, no urine output (anuria), nausea, vomiting, changes in thinking caused by kidney failure and build-up of toxic chemicals in the blood, and severe abdominal pain with hemorrhaging (due to death of intestinal tissue). The outlook will depend on the extent of the problem and the amount of damage to the kidneys. The kidney damage may be temporary or permanent.

Raynaud’s (ray-NOHZ) disease causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. In Raynaud’s disease, smaller arteries that supply blood to your skin narrow, limiting blood circulation to affected areas (vasospasm). Women are more likely than men to have Raynaud’s disease, also known as Raynaud or Raynaud’s phenomenon or syndrome. It appears to be more common in people who live in colder climates.

Rheumatic fever is an inflammatory autoimmune disease that may develop after an infection with group A Streptococcus bacteria (such as strep throat or scarlet fever). The disease can affect the heart, joints, skin, and brain. Rheumatic fever is common worldwide and is responsible for many cases of damaged heart valves. It is not common in the United States, and usually occurs in isolated outbreaks. The latest outbreak was in the 1980s. Rheumatic fever mainly affects children ages 5 -15, and occurs approximately 14-28 days after strep throat or scarlet fever. Symptoms include: abdominal pain, fever, heart (cardiac) problems, which may not have symptoms, or may result in shortness of breath and chest pain, joint pain, arthritis (mainly in the knees, elbows, ankles, and wrists), joint swelling; redness or warmth, nosebleeds (epistaxis), skin nodules, skin rash, skin eruption on the trunk and upper part of the arms or legs, eruptions that look ring-shaped or snake-like, and sydenham chorea (emotional instability, muscle weakness and quick, uncoordinated jerky movements that mainly affect the face, feet, and hands). If you are diagnosed with acute rheumatic fever you will be treated with antibiotics. Anti-inflammatory medications such as aspirin or corticosteroids reduce inflammation to help manage acute rheumatic fever. If rheumatic fever returns, your doctor may recommend you take low-dose antibiotics continually, especially during the first 3 -5 years after the first episode of the disease. Heart complications may be severe, particularly if the heart valves are involved.

Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers. More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. But children and young adults can also get it. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime. Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body’s own tissues. No one knows what causes rheumatoid arthritis. Genes, environment and hormones might contribute. Treatments include medicine, lifestyle changes and surgery. These can slow or stop joint damage and reduce pain and swelling.

Rheumatoid Arthritis of the Foot and Ankle. Rheumatoid arthritis is a chronic disease that attacks multiple joints throughout the body. It most often starts in the small joints of the hands and feet, and usually affects the same joints on both sides of the body.

A rotator cuff tear is a tear of one or more of the tendons of the four rotator cuff muscles of the shoulder. A rotator cuff ‘injury’ can include any type of irritation or overuse of those muscles or tendons, and is among the most common conditions affecting the shoulder.

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Sarcoidosis is an autoimmune disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. It starts as tiny, grain-like lumps, called granulomas. Sarcoidosis can affect any organ in your body. No one is sure what causes sarcoidosis. It affects men and women of all ages and races. It occurs mostly in people ages 20 to 50, African Americans, especially women, and people of Northern European origin. Many people have no symptoms. If you have symptoms, they may include: cough, shortness of breath, weight loss, night sweats, and fatigue. Tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. Not everyone who has the disease needs treatment. If you do, prednisone, a type of steroid, is the main treatment.

Schmidt syndrome also known as Polyglandular autoimmune syndrome type 2 is a rare autoimmune syndrome that commonly has the constellation of three diseases: diabetes mellitus type 1, hypothyroidism and adrenal insufficiency. Owing to the diabetes mellitus type 1, patients require life-long insulin therapy and blood glucose levels need to be monitored. They are at risk for chronic complications of diabetes such as neuropathy, nephropathy and retinopathy. More acutely, due to fluctuations in blood glucose levels, they are at risk for hypoglycemia with neuroglycopenic symptoms and ketoacidosis. Hypothyroidism is diagnosed by measuring the thyroid hormone levels and if inappropriately low is treated with replacement therapy. Patients with adrenal insufficiency experience symptoms due to low glucocorticoid and mineralocorticoid levels in the body, due to decreased or absent production.

Sciatica refers to pain that radiates along the path of the sciatic nerve, which branches from your lower back through your hips and buttocks and down each leg. Typically, sciatica affects only one side of your body. Sciatica most commonly occurs when a herniated disk, bone spur on the spine or narrowing of the spine (spinal stenosis) compresses part of the nerve. This causes inflammation, pain and often some numbness in the affected leg.

Scleritis is an inflammation of the sclera (the white outer wall of the eye). Inflammation of the sclera is often linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Sometimes the cause is unknown. Scleritis occurs most often in people between the ages of 30 and 60. It is rare in children. Symptoms of scleritis include: blurred vision, eye pain and tenderness, red patches on the normally white part of the eye, sensitivity to light, and tearing of the eye. A rare form of this disease causes no eye pain or redness. In most cases, the condition goes away with treatment. But it may come back. The disorder causing scleritis may be serious. However, it may not be discovered the first time you have the problem. The outcome will depend on the specific disorder.

Scleroderma means hard skin. It is an autoimmune related disease that causes abnormal growth of connective tissue. Connective tissue is the material inside your body that gives your tissues their shape and helps keep them strong. In scleroderma, the tissue gets hard or thick. It can cause swelling or pain in your muscles and joints. Symptoms of scleroderma include: calcium deposits in connective tissues, Raynaud’s phenomenon, a narrowing of blood vessels in the hands or feet, swelling of the esophagus, thick, tight skin on your fingers, and red spots on your hands and face. No one knows what causes scleroderma. It is more common in women. It can be mild or severe. Doctors diagnose scleroderma using your medical history, a physical exam, lab tests, and a skin biopsy. There is no cure, but various treatments can control symptoms and complications.

Sexual dysfunction is any physical or psychological problem that prevents you or your partner from getting sexual satisfaction. The main types of male sexual dysfunction are: Erectile dysfunction (difficulty getting/keeping an erection) Premature ejaculation (reaching orgasm too quickly).

Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.

Shin splints, also known as medial tibial stress syndrome (MTSS), is defined by the American Academy of Orthopaedic Surgeons as “pain along the inner edge of the shinbone. (tibia).” Shin splints are usually caused by repeated trauma to the connective muscle tissue surrounding the tibia.

Shoulder pain may arise from the shoulder joint itself or from any of the many surrounding muscles, ligaments or tendons. Shoulder pain that comes from the joint usually worsens with activities or movement of your arm or shoulder.

Multiple system atrophy (MSA), also known as Shy–Drager syndrome, is a rare neurodegenerative disorder characterized by tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) due to dysfunction of the autonomic nervous system, and ataxia.

Inflammation of the lining membrane in any of the hollow areas (sinuses) of the skull around the nose. Sinusitis may be caused by anything that interferes with air flow into the sinuses and the drainage of mucous out of the sinuses. The sinus openings, called ostia, may be obstructed by swelling of the tissue lining the ostia and adjacent nasal passage tissue; for example, from colds, allergies, and tissue irritants (nasal sprays, cocaine, cigarette smoke). Less commonly, sinuses can become obstructed by tumors or growths. Stagnated mucous then provides a perfect environment for bacterial infection. The common symptoms of sinusitis include headache; facial tenderness or pain; fever; cloudy, discolored nasal drainage; a feeling of nasal stuffiness; sore throat; and cough. Acute sinusitis is usually treated with antibiotic therapy. Chronic forms of sinusitis require long courses of antibiotics and may require a sinus drainage procedure.

Sjögren’s syndrome is a disease that causes dryness in your mouth and eyes. It can also lead to dryness in other places that need moisture, such as your nose, throat and skin. Most people who get Sjogren’s syndrome are older than 40, nine of 10 are women. Sjogren’s syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis. Sjogren’s syndrome is an autoimmune disease. If you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. In Sjogren’s syndrome, your immune system attacks the glands that make tears and saliva. It may also affect your joints, lungs, kidneys, blood vessels, digestive organs, and nerves. The main symptoms are dry eyes, and dry mouth. Treatment focuses on relieving symptoms.

Facial or other skin rejuvenation is a cosmetic treatment (or series of cosmetic treatments), which aims to restore a youthful appearance to the human face. Facial rejuvenation can be achieved through either surgical and/or non-surgical options. Procedures can vary in invasiveness and depth of treatment.

In the event of an injury that damages the skin’s protective barrier, the body triggers a response called wound healing. After hemostasis, inflammation white blood cells, including phagocytic macrophages arrive at the injury site. Once the invading microorganisms have been brought under control, the skin proceeds to heal itself. The ability of the skin to heal even after considerable damage has occurred is due to the presence of stem cells in the dermis and cells in the stratum basale of the epidermis, all of which can generate new tissue.

A SLAP tear is an injury to the labrum of the shoulder, which is the ring of cartilage that surrounds the socket of the shoulder joint. SLAP lesion is an injury to the glenoid labrum (fibrocartilaginous rim attached around the margin of the glenoid cavity). SLAP is an acronym for “superior labral tear from anterior to posterior”.

Sperm & testicular autoimmunity – The human immune system is trained during the early postnatal period. In men, at puberty when the sperm first appear in the testis and epididymis, the human immune system will have the chance to contact sperm antigens. Similarly, when women become sexually active, their immune system will inevitably contact sperm antigens. Therefore, once sperm, as an autoantigen, activates the human immune system, an autoimmune response against human sperm will occur. The blood-testis barrier and the epididymal blood-epithelium barrier in humans are important structures in preventing sperm antigens from contacting immunocompetent cells, due to the tight junctions of Sertoli and epithelial cells. This creates favorable conditions for spermatogenesis and sperm survival in the testicular fluid, and sperm maturation in the epididymal fluid. It also prevents the occurrence of autoimmunity after puberty. Therefore, alteration of the blood-testis barrier and the blood-epithelium barrier allows the production of ASAs and, hence, may lead to infertility. There are three types of sperm autoimmunity: that associated with genital tract obstruction, that accompanied by testicular inflammation, and a spontaneously occurring type that does not present with either of the preceding associated features.

A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cord below the level of the injury.

Incomplete Spinal Cord Injury. An incomplete injury means that some nerve signals can still be sent along the spinal cord to the brain, even from below the injury site. You may have some movement and sensation with an incomplete injury.

Degenerative Disc Disease Definition. Degenerative Disc Disease is a general term for the condition in which a damaged vertebral disc causes chronic pain – either low back pain (and/or leg pain, sciatica) in the lumbar spine or neck pain (and/or arm pain) in the cervical spine.

Osteoarthritis and the spine. Due to the amount of pressure they withstand, the spinal joints are particularly prone to developing arthritis. Generally speaking, spinal arthritis occurs in the facet joints, or vertebral joints. Arthritis of the facet joints can cause slight to severe pain.

Your body’s facet joints are the joints on the back of your spine that counterbalance the disks inside your spine’s vertebrae. They’re important for limiting the motion of your spine so that the vertebrae stay in proper alignment. Over time, aging causes the facet joints to wear down. Arthritis of these joints may also occur over time, just as it might in any other joint. This is referred to as facet arthropathy.

Accidents, poor training practices, or improper gear can cause them. Some people get hurt because they are not in shape. Not warming up or stretching enough can also lead to injuries. The most common sports injuries are: * Sprains and strains * Knee injuries * Swollen muscles * Achilles tendon injuries * Pain along the shin bone * Rotator cuff injuries * Fractures * Dislocations

A sprained ankle is an injury that occurs when you roll, twist or turn your ankle in an awkward way. This can stretch or tear the tough bands of tissue (ligaments) that help hold your ankle bones together. Ligaments help stabilize joints, preventing excessive movement.

Stargardt disease. Stargardt disease: An hereditary eye disease that is one of the most frequent causes of macular degeneration in childhood. (The macula is the part of the retina that is responsible for central vision.)

Steinert’s disease, this form is characterized by an inability to relax muscles at will following contractions. Myotonic muscular dystrophy is the most common form of adult-onset muscular dystrophy. Facial and neck muscles are usually the first to be affected.

Spinal stenosis is a narrowing of the spaces within your spine, which can put pressure on the nerves that travel through the spine. Spinal stenosis occurs most often in the lower back and the neck. Some people with spinal stenosis may not have symptoms. Others may experience pain, tingling, numbness and muscle weakness. Symptoms can worsen over time. Spinal stenosis is most commonly caused by wear-and-tear changes in the spine related to osteoarthritis. In severe cases of spinal stenosis, doctors may recommend surgery to create additional space for the spinal cord or nerves.

Stiff person syndrome (SPS) is a rare disease of the nervous system. Progressively severe muscle stiffness typically develops in the spine and lower extremities; often beginning very subtly during a period of emotional stress. Most patients experience painful episodic muscle spasms that are triggered by sudden stimuli. An autoimmune component is typical and patients often have other autoimmune disorders. Symptoms usually begin in the mid forties. Although it is not possible to determine the exact prevalence, it may occur in fewer that 1 per million. The disease is more common in women (the ratio is 2 women for every man affected). There is no predilection for any race or ethnic group. There is an association with diabetes and perhaps over half of patients with SPS have or will develop diabetes. Other autoimmune diseases have been found in association with SPS, for example: thyroid disease and vitiligo. There is an increased incidence of epilepsy. An important but especially rare variant of SPS is associated with breast or lung cancer. Although SPS is a serious potentially life-threatening disease, and some of the treatments have serious potential side effects; the course of SPS is variable. There are patients who, with proper treatment, are able to return to activities they enjoy.

Adult Still’s disease is a rare type of inflammatory arthritis that features fevers, rash, and joint pain. Some people have just one episode of adult Still’s disease. In other people, the condition persists or recurs. This inflammation can destroy affected joints, particularly the wrists. Treatment involves medications, such as prednisone, that help control inflammation.

A stroke occurs when the blood supply to part of your brain is interrupted or reduced, depriving brain tissue of oxygen and nutrients. A stroke is a medical emergency. Prompt treatment is crucial. Early action can minimize brain damage and potential complications.

After a stroke, many patients still have problems with physical, speech, and mental functions. Rehabilitation for these problems can be provided in a variety of settings. Rehabilitation programs are critical in helping patients regain lost skills, relearn tasks, and work to be independent again. In many cases, there is great potential for the brain to recover.

Subacute bacterial endocarditis (SBE) (also called endocarditis lenta) is a type of endocarditis (more specifically, infective endocarditis). It is usually caused by a form of streptococci viridans bacteria that normally live in the mouth and throat (Streptococcus mutans, mitis, sanguis or milleri). Other strains of streptococci (bovis and equines) can also cause subacute endocarditis, usually in patients who have a form of gastrointestinal cancer. Additional causes are Enterococci (urinary tract infections) and coagulase negative staphylococci such as Staphylococcus epidermidis (skin). Underlying structural valve disease is usually present in patients before developing subacute endocarditis. It is less likely to lead to septic emboli than is acute endocarditis.

Susac’s syndrome is a very rare autoimmune related disease, of still unknown etiology, and many persons who experience it do not display the bizarre symptoms named here. Often sufferers experience a personality change and develop bizarre and paranoid behavior. Their speech can be affected, such as the case of a female of late teens who suffered speech issues and hearing problems, and many experience unrelenting and intense headaches and migraines, some form of hearing loss, and impaired vision. The problem usually corrects itself, but this can take up to five years. In some cases, subjects can become confused. The syndrome usually affects women around the age of 18 years old, with female to male ratio of cases of 2:1.

Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of both eyes following trauma to one eye. It can leave the patient completely blind. Symptoms may develop from days to several years after a penetrating eye injury. Sympathetic ophthalmia is rare, affecting 0.2% to 0.5% of non-surgical eye wounds, and less than 0.01% of surgical penetrating eye wounds. There are no gender or racial differences in incidence of SO. Eye floaters and loss of accommodation are among the earliest symptoms. Once SO is developed, Immunosuppressive therapy is the mainstay of treatment. When initiated promptly following injury, it is effective in controlling the inflammation and improving the prognosis. Mild cases may be treated with local application of corticosteroids and pupillary dilators.

T

Takayasu’s arteritis is a chronic inflammatory autoimmune condition that affects the largest blood vessel in the body (the aorta) and its branches. Thus, the complications of Takayasu’s arise directly or indirectly from damage to these blood vessels. The vasculitides are classified according to the size of blood vessel involved. Takayasu’s is the classic “large vessel” vasculitis. Takayasu’s arteritis is occasionally called “pulseless disease”, because of the difficulty in detecting peripheral pulses that sometimes occurs as a result of the vascular narrowings. The “typical” patient with Takayasu’s arteritis is a woman under the age of 40. There is a 9:1 female predominance in this disease. Although the disease has a worldwide distribution, it appears to occur more often in Asian women. Takayasu’s arteritis is a rare disease. The best estimates of the disease frequency suggest that 2 or 3 cases occur each year per million people in a population. Because TAK can cause heart problems, high blood pressure and stroke, patients with TAK should talk to their doctor about ways to lower the risk of these serious problems.

Tarsal tunnel syndrome (TTS), also known as posterior tibial neuralgia, is a compression neuropathy and painful foot condition in which the tibial nerve is compressed as it travels through the tarsal tunnel.

Temporal arteritis/Giant cell arteritis is inflammation and damage to the blood vessels that supply blood to the head. If the inflammation affects the arteries in your neck, upper body and arms, it is called giant cell arteritis. Temporal, giant cell, and cranial arteritis occur when one or more arteries become inflamed, swollen, and tender. Temporal arteritis commonly occurs in the arteries around the temples (temporal arteries). These vessels branch off from the carotid artery in the neck. However, the condition can occur in medium-to-large arteries in other places in the body. The cause of the condition is unknown. It is believed to be due in part to a faulty immune response. The disorder has been linked to severe infections and the use of high doses of antibiotics. The problem may develop with or following another inflammatory disorder known as polymyalgia rheumatica. Giant cell arteritis almost always occurs in people over age 50. It is rare in people of African descent. The condition may run in families. Some common symptoms of this problem are throbbing headache on one side of the head or the back of the head and tenderness when touching the scalp. Most people make a full recovery, but treatment may be needed for 1 to 2 years or longer. The condition may return at a later date. Damage to other blood vessels in the body such as aneurysms (ballooning of the blood vessels) may occur. This damage can lead to a stroke in the future.

The temporomandibular (tem-puh-roe-mun-DIB-u-lur) joint (TMJ) acts like a sliding hinge, connecting your jawbone to your skull. You have one joint on each side of your jaw. TMJ disorders — a type of temporomandibular disorder or TMD — can cause pain in your jaw joint and in the muscles that control jaw movement. The exact cause of a person’s TMJ disorder is often difficult to determine. Your pain may be due to a combination of factors, such as genetics, arthritis or jaw injury. Some people who have jaw pain also tend to clench or grind their teeth, although many people habitually clench or grind their teeth and never develop TMJ disorders. In most cases, the pain and discomfort associated with TMJ disorders is temporary and can be relieved with self-managed care or nonsurgical treatments. Surgery is typically a last resort after conservative measures have failed, but some people with TMJ disorders may benefit from surgical treatments.

Tendons may also attach muscles to structures such as the eyeball. A tendon serves to move the bone or structure. A ligament is a fibrous connective tissue which attaches bone to bone, and usually serves to hold structures together and keep them stable. A sprain is a stretching or tearing of ligaments — the tough bands of fibrous tissue that connect two bones together in your joints. The most common location for a sprain is in your ankle. A strain is a stretching or tearing of muscle or tendon. A tendon is a fibrous cord of tissue that connects muscles to bones.

Tennis elbow, also known as lateral epicondylitis, is a condition in which the outer part of the elbow becomes painful and tender. The pain may also extend into the back of the forearm and grip strength may be weak. It is due to excessive use of the muscles of the back of the forearm.

A tension headache is generally a diffuse, mild to moderate pain in your head that’s often described as feeling like a tight band around your head. A tension headache (tension-type headache) is the most common type of headache, and yet its causes aren’t well-understood.

Testicular atrophy is a medical condition in which the male reproductive organs (the testes, which in humans are located in the scrotum) diminish in size and may be accompanied by loss of function. This does not refer to temporary changes, such as those brought on by cold.

see entry for Immune thrombocytopenic purpura (ITP)

Tinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. A common problem, tinnitus affects about 1 in 5 people. Tinnitus isn’t a condition itself — it’s a symptom of an underlying condition, such as age-related hearing loss, ear injury or a circulatory system disorder. Although bothersome, tinnitus usually isn’t a sign of something serious. Although it can worsen with age, for many people, tinnitus can improve with treatment. Treating an identified underlying cause sometimes helps. Other treatments reduce or mask the noise, making tinnitus less noticeable.

Tolosa-Hunt syndrome (THS) is a rare autoimmune related disorder characterized by severe and unilateral headaches with extraocular palsies, usually involving the third, fourth, fifth, and sixth cranial nerves, and pain around the sides and back of the eye, along with weakness and paralysis (ophthalmoplegia) of certain eye muscles. The exact cause of THS is not known, but the disorder is thought to be, and often assumed to be, associated with inflammation of the areas behind the eyes. Symptoms are usually limited to one side of the head, and in most cases the individual affected will experience intense, sharp pain and paralysis of muscles around the eye. Symptoms may subside without medical intervention, yet recur without a noticeable pattern. The prognosis of THS is usually considered good. Patients usually respond to corticosteroids, and spontaneous remission can occur, although movement of ocular muscles may remain damaged. Roughly 30–40% of patients who are treated for THS experience a relapse.

Transverse myelitis is a neurological disorder caused by inflammation across both sides of one level, or segment, of the spinal cord. The term myelitis refers to inflammation of the spinal cord; transverse simply describes the position of the inflammation, that is, across the width of the spinal cord. Attacks of inflammation can damage or destroy myelin, the fatty insulating substance that covers nerve cell fibers. This damage causes nervous system scars that interrupt communications between the nerves in the spinal cord and the rest of the body. Symptoms of transverse myelitis include a loss of spinal cord function over several hours to several weeks. What usually begins as a sudden onset of lower back pain, muscle weakness, or abnormal sensations in the toes and feet can rapidly progress to more severe symptoms, including paralysis, urinary retention, and loss of bowel control. Transverse myelitis often develops following viral infections and is considered to be autoimmune related. Although some patients recover from transverse myelitis with minor or no residual problems, others suffer permanent impairments that affect their ability to perform ordinary tasks of daily living. Most patients will have only one episode of transverse myelitis; a small percentage may have a recurrence. Transverse myelitis occurs in adults and children, in both genders, and in all races. No familial predisposition is apparent. A peak in incidence rates (the number of new cases per year) appears to occur between 10 and 19 years and 30 and 39 years. Although only a few studies have examined incidence rates, it is estimated that about 1,400 new cases of transverse myelitis are diagnosed each year in the United States, and approximately 33,000 Americans have some type of disability resulting from the disorder.

Traumatic brain injury usually results from a violent blow or jolt to the head or body. An object that penetrates brain tissue, such as a bullet or shattered piece of skull, also can cause traumatic brain injury. Mild traumatic brain injury may affect your brain cells temporarily.

The triangular fibrocartilage complex (TFCC) is a cartilage structure located on the small finger side of the wrist that, cushions and supports the small carpal bones in the wrist. The TFCC keeps the forearm bones (radius and ulna) stable when the hand grasps or the forearm rotates.

U

Ulcerative colitis (UC) is an autoimmune related disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. It is one of a group of diseases called inflammatory bowel disease. UC can happen at any age, but it usually starts between the ages of 15 and 30. It tends to run in families. The most common symptoms are pain in the abdomen and blood or pus in diarrhea. Other symptoms may include, anemia, severe tiredness, weight loss, loss of appetite, bleeding from the rectum, sores on the skin, joint pain, and growth failure in children. About half of people with UC have mild symptoms. Doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose UC. Several types of drugs can help control it. Some people have long periods of remission, when they are free of symptoms. In severe cases, doctors must remove the colon.

Undifferentiated connective tissue disease (UCTD) is a systemic autoimmune disease. This means the body’s natural immune system does not behave normally. Instead of serving to fight infections such as bacteria and viruses, the body’s own immune system attacks itself. In UCTD, autoimmunity may cause the immune system to attack specific parts of the body resulting in a variety of problems. The phrase “connective tissue disease” is used to describe the diseases of the immune system that are treated primarily by rheumatologists. These represent systemic autoimmune diseases that often involve the joints, cartilage, muscles, and skin. They can also involve any other organ system such as the eyes, heart, lungs, kidneys, gastrointestinal tract, bone marrow, nervous system, and blood vessels. Examples of connective tissue diseases include lupus, scleroderma, rheumatoid arthritis, Sjögren’s syndrome, myositis, and vasculitis. There are many people who have features of connective tissue disease; however, they do not fulfill the diagnostic criteria established for any one disease. In such circumstances, they are often considered to have “undifferentiated” connective tissue disease. Over time, people with UCTD may evolve into one of the more specific connective tissue diseases, such as lupus, Sjögren’s or scleroderma.

Chronic urticaria is defined as hives, typically occurring daily, for greater than 6 weeks duration. Over half of all cases of chronic idiopathic urticaria are thought to occur by an autoimmune mechanism, primarily autoantibodies against the high affinity immunoglobulin E (IgE) receptor (FcεRI). Chronic autoimmune urticaria has been found to be associated with autoimmune thyroid disease. The treatment of chronic autoimmune urticaria, as in chronic idiopathic urticaria, is with H1 antihistamines. Urticaria is not a single disease but a reaction pattern that represents cutaneous mast cell degranulation, with the condition being defined as chronic if lesions recur for longer than 6 weeks. Mast cell degranulation results in extravasation of plasma into the dermis, forming characteristic hives—edematous pruritic pink wheals of variable size and shape, with or without accompanying angioedema. In angioedema, the swelling is deeper than wheals and may affect mucosal surfaces. Erythema is often absent in angioedema, and typical sites of predilection include the eyelids, lips, and tongue.

Uveitis is swelling and irritation of the uvea, the middle layer of the eye. The uvea provides most of the blood supply to the retina. Uveitis can be caused by autoimmune disorders, including rheumatoid arthritis or ankylosing spondylitis. It can also be caused by infection or exposure to toxins. In many cases, the cause is unknown. The most common form of uveitis is anterior uveitis. This involves inflammation in the front part of the eye. It is often called iritis because it usually only affects the iris, the colored part of the eye. The disorder may affect only one eye. The inflammation may be linked with autoimmune diseases, but most cases occur in healthy people. It is most common in young and middle-aged people. Symptoms may develop rapidly and can include: blurred vision, dark, floating spots in the vision, eye pain, redness of the eye, and sensitivity to light. With proper treatment, most attacks of anterior uveitis go away in a few days to weeks. However, the problem often returns.

V

Vaginal tissue and urethral mucosa are altered as a result of the diminished amount of circulating estrogen. Estrogen-based treatments have been shown to be effective. However, many patients are reluctant to be treated with such formulations due to health concerns, so we need to assess the efficacy of acceptable alternatives. Stem cells and PRP promotes tissue repair and influences in angiogenesis and inflammation reduction and can enhance healing and regeneration of various tissues.

Varicose veins are veins that have become enlarged and twisted. The term commonly refers to the veins on the leg, although varicose veins can occur elsewhere. Veins have pairs of leaflet valves to prevent blood from flowing backwards (retrograde flow or venous reflux).

Vascular disease is a class of diseases of the blood vessels – the arteries and veins of the circulatory system of the body. It is a subgroup of cardiovascular disease. Disorders in this vast network of blood vessels, can cause a range of health problems which can be severe or prove fatal.

Venous ulcers (venous insufficiency ulceration, stasis ulcers, stasis dermatitis, varicose ulcers, or ulcus cruris) are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs (hence leg ulcers).

Vasculitis is an autoimmune related inflammation of the blood vessels. It happens when the body’s immune system attacks the blood vessel by mistake. It can happen because of an infection, a medicine, or another disease. The cause is often unknown. Vasculitis can affect arteries, veins and capillaries. Arteries are vessels that carry blood from the heart to the body’s organs. Veins are the vessels that carry blood back to the heart. Capillaries are tiny blood vessels that connect the small arteries and veins. When a blood vessel becomes inflamed, it can narrow, making it more difficult for blood to get through, close off completely so that blood can’t get through, or stretch and weaken so much that it bulges. The bulge is called an aneurysm. If it bursts, it can cause dangerous bleeding inside the body. Symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. The main goal of treatment is to stop the inflammation. Steroids and other medicines to stop inflammation are often helpful.

Vitiligo causes white patches on your skin. It can also affect your eyes, mouth, and nose. It occurs when the cells that give your skin its color are destroyed. No one knows what destroys them. It is more common in people with autoimmune diseases, and it might run in families. It usually starts before age 40. The white patches are more common where your skin is exposed to the sun. In some cases, the patches spread. Vitiligo can cause your hair to gray early. If you have dark skin, you may lose color inside your mouth. Using sunscreen will help protect your skin, and cosmetics can cover up the patches. Treatments for vitiligo include medicines, light therapy, and surgery. Not every treatment is right for everyone. Many have side effects. Some take a long time. Some do not always work.

Vogt-Koyanagi-Harada disease is a rare disorder of unknown origin that affects many body systems, including as the eyes, ears, skin, and the covering of the brain and spinal cord (the meninges). The most noticeable symptom is a rapid loss of vision. There may also be neurological signs such as severe headache, vertigo, nausea, and drowsiness. Loss of hearing, and loss of hair (alopecia) and skin color may occur along, with whitening (loss of pigmentation) of the hair and eyelashes (poliosis).

W

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue.

Maintaining an optimal level of wellness is absolutely crucial to live a higher quality life. Wellness matters. Wellness matters because everything we do and every emotion we feel relates to our well-being. In turn, our well-being directly affects our actions and emotions. It’s an ongoing circle. Therefore, it is important for everyone to achieve optimal wellness in order to subdue stress, reduce the risk of illness and ensure positive interactions.

Whiplash is a neck injury due to forceful, rapid back-and-forth movement of the neck, like the cracking of a whip. Whiplash most often occurs during a rear-end auto accident, but the injury can also result from a sports accident, physical abuse or other trauma. Common signs and symptoms of whiplash include neck pain, stiffness and headaches. Most people with whiplash get better within a few weeks by following a treatment plan that includes pain medication and exercise. However, some people have chronic neck pain and other long-lasting complications. Whiplash may be called a neck sprain or strain, but these terms also include other types of neck injuries.

Skin, the largest organ of the body, has multiple important functions, such as acts as a barrier to foreign pathogens, regulates body temperature, supplies sensation, and prevents dehydration of the body. An open wound could be defined as a type of injury in which the skin is torn, cut, or punctured resulting in disruption of normal anatomic structure and function. Normal wound healing process is composed of a well-orchestrated process of cell migration, proliferation, and extracellular matrix deposition undergoing three overlapping but distinct phases of inflammation, proliferation, and maturation and is a critical survival factor for an individual. Disruption of the cellular and molecular signals in conditions such as diabetes, infection, or radiation exposure may result in an inefficient healing. The skin wound might be of different nature and varies from surgical to accidental lacerations, burns, pressure ulcers, diabetic ulcers, and venous ulcers.

A wrinkle, also known as a rhytide, is a fold, ridge or crease in the skin or on fabric. Skin wrinkles typically appear as a result of aging processes such as glycation, habitual sleeping positions, loss of body mass, or temporarily, as the result of prolonged immersion in water. Age wrinkling in the skin is promoted by habitual facial expressions, aging, sun damage, smoking, poor hydration, and various other factors.

Wrist pain is often caused by sprains or fractures from sudden injuries. But wrist pain can also result from long-term problems, such as repetitive stress, arthritis and carpal tunnel syndrome.

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